L7 Sleep, Decision-Making Flashcards
Circadian cycle
evolved to maintain appropriate daily rhythms and hmeostatic functions with variable daylight in variable seasons
Cells of Circadian Cycle
Photosensitive ganglion cells that detect the cues for the clock
contain photopigment called melanopsin and are depolarized by light
help to encode illumination, allow for reset of circadian clock
project to the suprachiasmatic nucleus (SCN), which controls the circadian cycle
Melatonin
produced by the pineal gland
modulates neural activity by activating melatonin receptors on neurons in SCN
Orexin
promotes wakefulness, from the hypothalamus
Suprachiasmatic nucleus
governs physiologic responses associated with sleep wake cycle including BP, hormone secretion, body temp, urine output
Even with light cues removed…
individuals present with a 24 hour clock
Sleep
defined behaviorally by the normal suspension of consciousness and electrophysiologically by specific wave critera
Sleep deprivation
can be deleterious and even fatal
can also call mood swings, hallucinations
Sleep is not just a downregulation of brain activity…
series of precisely controlled physiological states governed by brainstem nuclei
high levels of brain activity occurs
Amount of sleep required
Adults: 7-8
Teens: 9
Babies: more
Sleep debt
getting too little sleep that has to be made up
judgement, reaction time, memory, cognitive, other functions are impaired
What are the purposes of sleep?
- Energy conservation
- Memory Consolidation
- Metabolic wastes cleared from brain
- We are dependent on visual info to find food, need to avoid predators
Energy conservation and sleep
sleep replenishes brain glycogen levels
minimize heat loss by dropping body temp
metabolism is decreased during slep
Fatal Familial Insomnia
Genetic disorder that causes death within several years of onset, unable to enter REM sleep
Stage 2 Sleep
further decrease in frequency of EEG waves and increase in the amplitude, also has high frequency spike clusters called sleep spindles
Stages of Sleep
defined by the amount of electroencephalographic energy recorded
Stage 1 Sleep
Drowsy period
decrease in EEG frequency, increased amplitude
Sleep Spindles
periodic bursts of activity at about 10 to 12 Hz that generally last 1 to 2 seconds and arise as a result of interactions between thalamic and cortical neurons
Stage 3 Sleep
moderate to deep sleep
number of sleep spindles decreases
amplitude of EEG increases, frequency decreases
Stage 4 Sleep
deepest level of sleep
low level of EEG frequency, high amplitude fluctuations (delta waves)
takes about an hour to reach this stage
Slow wave cycle
Stage 3 and Stage 4
Non-REM sleep
Stages 1-4
REM Sleep
EEG recordings are similar to as when you are awake
after about 10 minutes in REM, the brain cycles to the other 4 stages
about 4 periods of REM sleep occur
Stage 1 Physiological Changes
slow, rolling eye movements
decrease in muscle tone, body movements, heart rate, breathing, BP, metabolic rate, temperature
(reach their lowest values in stage 4)