Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharma > L7 Anti-D > Flashcards

L7 Anti-D Flashcards

1
Q

Anti-depressants Classification

A
  1. Selective serotonin reuptake inhibitors (SSRIs)
  2. Serotonin-Norephenephrine reuptake inhibitors (SNRIs)
  3. Tricyclic Anti-depressans
  4. Monoamine oxidase inhibitors
  5. Atypical antidepressants

Note.
H2-receptors inhibitors are anti-antidepressants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Most currently used anti-depressants primarily act on ?

A

metabolism or re-uptake of nor-adrenaline, or serotonin or both & increase stores & release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Amine Re-uptake Inhibitors (ARIs) :

A

-A. Tricyclic anti-depressants
-B. Heterocyclic (atypical) anti-depressants
-C. Serotonin & Nor-adrenaline Re-uptake Inhibitors (SNARI):
-D. Selective Serotonin Re-uptake Inhibitors: (SSRI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

A. Tricyclic anti-depressants :

A

(Ami-triptyline, Nor-triptyline, Pro-triptyline, Imipramine, Clomipramine,Doxipine , Maptroline)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

• Mechanism of Tricyclic anti-depressants ?

A

• decrease reuptake of NE, & 5-HT. ↑ in synaptic amines possibly related to anti-depressant effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

• Therapeutic Uses of Tricyclic anti-depressants ?

A

• Moderate to severe major depression
• Imipramine is used to control bed-wetting in children
• Migraine headache
• Chronic pain (neuropathic pain)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Tricyclic anti-depressants Adverse effects?

A

-Antimuscarinic:
Blurred vision, dry mouth, tachycardia, confusion constipation & urine retention
(Not used in glaucoma & BPH)

interactions. Direct acting sympathomimetic drugs (enhance activity), MAO inhibitors (enhance activity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

D. Selective Serotonin Re-uptake Inhibitors: (SSRI)

A

1st ( Drugs of choice for depression)
• (Paroxitine , Fluoxetine, Fluvoxamine, Citalopram Ecitalopram, Sertraline)
• Mechanism:
• More selectively inhibit reuptake of 5-HT( Serotonin).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Therapeutic uses of SSRI?

A

OCD( Fluoitine, flavoxamine )
Panic
post-traumatic stress disorder,
Depression
Generalized anxiety disorder,
SSRIs produce antidepressant effect at least after 2weeks.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Bulimia nervosa treated by?

A

(Only fluoxitine is approved)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

-has anti-psychotic effect ,block D 2 receptors, more suitable for depression in psychotic patients ?

A

Amoxapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

B. Heterocyclic (atypical) anti-depressants MOA?

A

Dec. reuptake of NE & 5-HT.
Bupropion also dec. reuptake of DA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

anti-depressants can aggravate psychosis & seizures?

A

Bupropion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Serotonin & Nor-adrenaline Re-uptake Inhibitors:
(SNARI):

A

Venlafaxine, Duloxitin

More effective in painful depression specially duloxitine

Dec. reuptake of 5-HT & to lesser extent NE
In low doses works like SSRIs & higher doses as TCAs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Adverse effects of SNARI ?

A

hypertension , cause constipation, increase in heart rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Indications (Uses) of anti-depressants ?

A

Depression
Anxiety disorders
Chronic pain
Enuresis

17
Q

• Obsessive-compulsive disorders we use?

A

• SSRIs (fluoxetine & fluvoxamine)

18
Q

• Chronic pain we use?

A

TSAs & venlafaxine

19
Q

• Enuresis we use?

A

TCAs

20
Q

• Attention deficit hyperkinetic disorder we use?

A

Imipramine & Atomoxetine

21
Q

Treatment of mania & bipolar disorder?

A

Lithium.(Mood stabilizer).

22
Q

Lithium adverse effects?

A

Polydipsia, polyurea, Polyphagia
fine hand tremors, sedation

23
Q

II. Mono-amine oxidase Inhibitors (MAOIs):

A

• Tranylcypromine
• Selegiline, Moclobemide ( inhibit MAO-B )

24
Q

(cause hypertensive crises, if taken with cheese), also ( inhibit MAO-A & B) ?

A

Tranyl-cypromine

25
Q

………………..depletes stores of nor-adrenaline &
serotonin in axonal terminals of central neurons
& causes depression

A

Reserpine

26
Q

• Adverse effects of Heterocyclic AD

A

• Moderate anti-muscarinic & sedative effects
• Amoxapine can cause parkinsonism, akathesia
• & ↑ in prolactin

• Maprotiline can cause seizures & arrhythmias

• Trazodone is more sedating & induces sleep
• Bupropion can aggravate psychosis & seizures

Pharma (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions