L6: Suppositories Flashcards
In pessaries, anti microbial action is….
Mainly local.
Suppositories have what type of action?
Local and systemic.
In pessaries, hormonal action is….
Systemic and local.
Name an advantage of using suppositories and pessaries (systemic).
Absorb
Mucous membranes of rectum and vagina absorb many drugs
No pH or enzymatic activities of GI tract
Name an advantage of using suppositories and pessaries (systemic).
GI tracts
They can deliver drugs that may irritate the GI tract
Name an advantage of using suppositories and pessaries (systemic).
Liver
Drugs may bypass the liver after rectal absorption.
Name an advantage of using suppositories and pessaries (systemic).
Route
Effective route to treat patients with vomiting.
Name an advantage of using suppositories and pessaries (systemic).
Convenience
Convenient for old people or children
What are the two main types of bases used to prepare suppositories?
Fatty bases
Water soluble or water dispersible bases
Which type of base is always adopted?
Witepsol
Mixture of natural fatty acid triglycerides
What are the 3 fatty bases?
Witepsol
Massupol
Theobroma oil
Why is theobroma oil rare to use as a base now?
Low water absorbing capacity
Overheating may change it’s melting point
What are 2 water soluble bases?
Glycerol gelatin
Macrogols
What can happen to poorly packaged suppositories?
May give rise to staining, breakage or deformation by melting.
