L6 Post surgical wound healing

Question 1

Phases of postsurgical healing

Answer 1

Inflammation
Fibrobalstic granulation
Matrix formation and remodeling

Question 2

Healing first 24 hours

Answer 2

Neutrophils infiltrate CT

Epithelium migrates from wound margins

Question 3

Healing 1-3 days

Answer 3

Space narrows tooth-flap

Epithelial cells migrate over flap, contact tooth

Question 4

Healing 3-7 days

Answer 4

Migration continues
Neutrophils replaced my macros
Clot replaced by granulation tissue
Revascularization begins

Question 5

Healing 1 week

Answer 5

Epithelium attaches to root

Blood clot replaced by granulation tissue

Question 6

Healing 2 weeks

Answer 6

Collagen fibers parallel to tooth (nonfunctional)

Question 7

Healing 1 month

Answer 7

Gingival crevice fully epithelialized
Fibroblasts proliferate
Infalmmatory cells gone

Question 8

Healing 2 months

Answer 8

Collagen remodeled, crosslinked

Most strength is regained

Question 9

Bone loss after flap surgery
When does it die
Osteoclasts peak
How much bone

Answer 9

Superficial dies at 1-3 days
Osteoclasts peak at 4-6 days
1mm bone is lost

Question 10

Growth factors released from blood clot

Answer 10

PDGF
EGF
TGF-Beta

Question 11

PDGF

Answer 11

Fibroblast and macrophage migration
Fibroblast proliferation
Macrophage activation

Question 12

EGF

Answer 12

Epithelial proliferation

Question 13

TGF-Beta

Answer 13

Inflammatory cell migration

Fibroblast proliferation

Question 14

Factors released by fibroblasts and macrophages

Answer 14

TNF: activates endothelium, induced neutrophil migration

IL-1beta: endothelium, induces neutrophil migration

Question 15

Epithelial healing takes ____

Complete in _____

Answer 15

7-14 days

6-7 weeks for complete healing