L6 Linkage mapping and beyond Flashcards
Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins. In this process, particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA) produced from that gene.
Splicing sites
Within the intron, a donor site (5’ end of the intron), a branch site (near the 3’ end of the intron) and an acceptor site (3’ end of the intron) are required for splicing.
SNP
a variation in a single nucleotide that occurs at a specific position in the genome
Personalised medicine
medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease.
Genetics risk factor
Genetic variants contribute to the risk of developing common and complex diseases, such as cancer and diabetes
Power
The power of a binary hypothesis test is the probability that the test correctly rejects the null hypothesis (H0) when a specific alternative hypothesis (H1) is true
Confounding factors
variable that influences both the dependent variable and independent variable causing a spurious association
Transferability
Can the results be extrapolated?
Personalised medicine wheel
- pharmacogenomics
- personal genomics
- medicine
pharmacogenomics
the branch of genetics concerned with determining the likely response of an individual to therapeutic drugs.
minion platform
MinION is the only portable real-time device for DNA and RNA sequencing
Breeding values
Breeding value refers to the value of an animal in a breeding program for a particular trait
Genetic resources
Genetic resources (GRs) refer to genetic material of actual or potential value. Genetic material is any material of plant, animal, microbial or other origin containing functional units of heredity.
Pedigree method
see onenote
Marker assisted selection
see onenote
