L6 End

Question 1

Burkitts lymphoma presents as:

Answer 1

Rapidly growing tumour, daily increases in size, fatal if untreated. May involve CNS at extranodal sites, risk of tumour lysis syndrome (tumour breakdown)
Lots of division and apoptosis giving a ‘starry sky appearance’ on biopsy. Nightly assoc with EBV

Question 2

What is the chromosomal translocation causing Burkitts lymphoma?

Answer 2

t(8;14)(q24.1;q32) Myc and Igh

Question 3

Treatment of Burkitts

Answer 3

Intensive high dose chemo
Monoclonal antibody target to CD20 expressing B cells - Rituximab
Cure rate up to 80%
Older patients may not be able to tolerate treatment

Question 4

What epigenetics modifiers are used in combo with other cancer treatments to improve outcome?

Answer 4

Tet2(DNA meth)
IDH1/2 (DNA meth)
EZH2 (H3K27me)
ASXL1

Question 5

EZH2 can cause malignant haemopoiesis by:

Answer 5

Hypertrimethation of H3K27

Causes B cell NHL amongst other cancers

Question 6

The loss of EZH2 function by mutation has been documented in what haemopoietic cancers?

Answer 6

Myeloid malignancies and ALL