L6

Question 1

Inflammation

Answer 1

• A dynamic process of chemical and cytological reactions
• A response of vascularized tissues to infections and tissue damage
• Brings defense cells & molecules from the circulation to the infected sites
• A protective response that is essential for survival

Question 2

Concept of inflammation started

Answer 2

3000 BC in Egyptian civilization(papyrus)

Question 3

first person who put the 4 cardinal signs of inflammation

Answer 3

Roman celsus

Question 4

in 19th century put the 5th sign of inflammation

Answer 4

German Virchow

Question 5

said that inflammation isn’t a disease

Answer 5

Scottish hunter

Question 6

described the process of phagocytosis

Answer 6

Russian Metchnikoff

Question 7

describes histamine (inflammatory mediator)

Answer 7

20th century, Thomas Lewis

Question 8

Inflammation results in:

Answer 8

Accumulation of leukocytes
Accumulation of fluid in extravascular tissue
Systemic effects

Question 9

Inflammation aims

Answer 9

1- Elimination of the cause of cell injury
2- Elimination of the necrotic cells and tissue
3- Paves the way for repair
4- May lead to harmful results

Question 10

Without inflammation

Answer 10

Infections would go unchecked
Wounds would never heal
Injured tissues might remain permanent festering sores

Question 11

Excessive inflammatory reaction become the cause of disease:

Answer 11

Misdirected (autoimmune)
Immunological/hypersensitivity (allergies)
Prolonged (microbes resist eradication)

Question 12

Anti-inflammatory drugs would control the

Answer 12

harmful sequelae of inflammation rather than interfering with its beneficial effects

Question 13

Defective inflammation

Answer 13

is also responsible for serious illness as seen in cancer and immunocompromised patients

Question 14

Five Classic Signs of Acute Inflammation

Answer 14

1- Heat (Calor)
2- Redness (Rubor)
3- Swelling (Tumor)
4- Pain (Dolor)
5- Loss of function (Functio Laesa)

Question 15

Appendix

Answer 15

Appendicitis

Question 16

Dermis

Answer 16

Dermatitis

Question 17

Gallbladder

Answer 17

Cholecystitis

Question 18

Duodenum

Answer 18

Duodenitis

Question 19

Meninges

Answer 19

Meningitis

Question 20

Causes of inflammation

Answer 20

Microbial infections: bacteria, viruses, fungi, parasites
Immunologic: hypersensitivity, autoimmune reactions
Physical agents: trauma, heat, cold, ionizing radiation
Chemical agents: acids, alkali, bacterial toxins, metals
Foreign material: sutures, dirt
􏰀 Tissue necrosis: ischemic necrosis

Question 21

Participants (the players)

Answer 21

White blood cells and platelets
Plasma proteins
Endothelial cells and smooth muscles of vessels
Extracellular matrix and stromal cells

Question 22

Plasma proteins

Answer 22

􏰀 Coagulation / fibrinolytic system
􏰀 Kinin system
􏰀 Complement system

Question 23

Extracellular matrix and stromal cells

Answer 23

􏰀 Mast cells, fibroblasts, macrophages & lymphocytes

􏰀 Structural fibrous proteins, adhesive glycoproteins, proteoglycans, basement membrane