L5.drug Toxicity And Teratogenicity

Question 0

In what 3 ways are allergic reactions to a drug different than toxic reactions to a drug?

Answer 0

1. Response is unrelated to dose
2. Only occurs in susceptible individuals
3. Response is the same every time; unrelated to drug classification

Question 1

What is the formula for calculating Therapeutic index?

Answer 1

TI = LD50/ED50

Question 2

What are the 3 major criteria that characterize addiction?

Answer 2

1. It is a compulsive disorder
2. A substantial amount of a person’s day is spent
   
   • Thinking about doing/using it
   • Doing/using
   • Obtaining the necessary $ to continue using
3. High rate of recidivism

Question 3

Physical dependence to a drug often developes with prolonged use (i.e. coffee). How does the physical dependence generally present itself? Is physical dependance addiction?

Answer 3

Generally withdrawal symptoms present as effects opposite to that of the drug.
No, physical dependance is not a criterion for addiction.

Question 4

In the first 2 weeks after contraception are birth defects likely to develop? Why or why not?

Answer 4

No, the early embryo is generally passed out with the menstral cycle if a defect occurs

Question 5

What time period during pregnancy is a birth defect most likely to occur?

Answer 5

Three weeks to three months, during early organogenesis

Question 6

What results from the birth defect Phocomelia? What drug causes this defect?

Answer 6

‘Flipper limbs’

-Thalidamide, used as a sleeping aid, restricts blood vessel development