L50- Pharmacodynamics, potency Flashcards
name 4 different types of drug targets?
- receptors
- enzymes
- ion channels
- carrier molecules
what does affinity mean?
the ability for a drug to bind to a receptor , lower KA higher affinity
what does efficacy mean?
it I the ability of a drug receptor complex to produce an effect
what is the dissociation constant?
KD/KA
the higher the affinity of the drug for the receptor?
the lower the KA
the lower the KA ?
the lower concentration of drug is needed for 50% occupancy
what is an agonist?
it is a ligand that has a high affinity for the receptor and upon binding it activates a response to occur
what is an antagonist?
it is a ligand that has a high affinity for the receptor and upon binding it does not lead to a response
what is a partial agonist?
it is a ligand that has a high affinity for the receptor and upon binding is not able to elicit the maximum possible response that is produced by full agonists.
what is an inverse agonist?
it is a ligand that has a high affinity for the receptor and upon binding it deactivates slightly acid active receptors.
what does potency mean?
refers to the concentration of a drug that produces 50% of the maximum effect.
What does TI (Therapeutic index) mean?
how safe a drug is
what is the equation for TI
TI= LD50/ED50
What does LD50 mean?
lethal dose to 50% of the population in animal experiments.
what does ED50 mean?
the effective dose in 50% of animals.
