L5: Physiologicall- based pharmacokinetic modelling Flashcards
What could the developability assessment consist of?
Physico-chemical characterization
How many classes are the biopharmaceutical classification system divided into:
4
Where are the drugs usually absorbed?
Small intestine
What is the main function of the stomach?
Reservoir, with mechanic and enzymatic digestion
What is the main function of the small intestine?
Digestion, pH regulation and absorption
Why is the small intestine a good place for drug absorption?
Large surface area
Why do we use in vitro models?
Simple, cheap, robust, no ethical concern
Temperature is important to consider when designing a dissolution experiment
True
Type of medium is important to consider when designing a dissolution experiment
True
Volume is important to consider when designing a dissolution experiment
True
The pH stat-controlled lipolysis can mimic both digestion and absorption at the same time- True /False
False
In the dissolution/permeation model which side do you sample from?
Basal
Why do we use pharmacopoeial dissolution models?
Simple, cheap and robust
Why do we use intestinal and gastric biorelevant media?
To stimulate physiological conditions in the gastrointestinal tract for..
