L2: Drug discovery screening and fragment based drug discovery

Question 1

Drug discovery is the process by which?

Answer 1

New drugs are discovered

Question 2

Which of the following is NOT included in Drug Discovery?

Answer 2

Customer feedback

Question 3

Small molecule drugs include?

Answer 3

Organic molecule( <900 Doltons)

Question 4

Cells/microbiomes are NOT considered as drug modalities:

Answer 4

False

Question 5

Which of the followings are often NOT the features of small molecule drugs?

Answer 5

High solubility

Question 6

During Hit generation, Orthogonal assay is to:

Answer 6

Validate hits

Question 7

Hit-to-lead (H2L) is a process of finding a lead that has sufficient properties for obtaining proof-of-concept data in:

Answer 7

Animal disease model

Question 8

LO is abbreviation for:

Answer 8

Lead optimisation

Question 9

Challenge for Lead finding is:

Answer 9

Compounds are made early, but real test is late

Question 10

During lead optimisation, lipophilicity of drugs is important for the following features, except

Answer 10

Taste and color
(the following features are affinity, selectivity, safety, bioavailability, and safety)

Question 11

Fragment-based drug discovery (FBDD) is suitable for screening:

Answer 11

1.000-5.000 compounds of Mw 100-300 Da

Question 12

Which of the followings is not the feature of FBDD?

Answer 12

Compounds often get too big and lipophilic

Question 13

Which of the following is not a commonly-used technique for drug screening?

Answer 13

Electron microscopy

Question 14

Features of the SRP method NOT include

Answer 14

High protein consumption