L4 - Neurulation

Question 1

Apical basal polarity

Answer 1

Neural plate neuroepithelial cells are polarised
A band of F actin is at the apical side
- If this pulls tight, the cells are constricted and change shape

Question 2

During neurulation many molecules interact with

Answer 2

F-actin to make it constrict

They are also differently distributed to basal or apical edges

Question 3

Changes in cell shape are signalled by?

Answer 3

Folate leading to changes in tissue shape

Question 4

Deficiencies in folate

Answer 4

During neurulation a topologically flat surface pinches off to form the CNS
Deficiencies in folate can cause failure to close that tube - spina bifida

Question 5

Xenopus studies on neurulation

Answer 5

They have externally visible developing embryos
Key role of folate receptors at apical surface of the neural plate—where it interacts with cytoskeletal and adherens junction components