L30- Antidiabetic Drugs II (new agents) Flashcards
Incretin Analog = (1) / (2)
exenatide- analog of glucagon like polypeptide 1 (GLP-1)
Incretin secretion responds to (1) and then causes (2)
1- glucose in GIT lumen
2- enhances glucose-stimulated insulin secretion from β-cell
Exenatide:
- (1) route of administration
- (2) list all net effects
1- SQ
2:
- enhance glucose dep. insulin secretion
- suppresses postprandial glucagon release
- slows gastric emptying –> dec appetite
- may stimulate β-cell proliferation
Exenatide AEs
n/v/d
acute pancreatitis
Contraindicated in gastroparesis patients
DPP-IV inhibitors = (1)
- functions to inc (2) and (3)
- (4) route of administration
1- sitagliptin
2- GLP-1
3- insulin
4- oral
Sitagliptin AEs
pancreatitis
hypersensitivity rxns –> urticaria, angioedema, anaphylaxis, skin rxns (Steven-Johnson)
Amylin Analog = (1):
- (2) normal function of peptide
- (3) route of administration
1- pramlintide
2- co-secreted with insulin (β-cells) –> inhibits food intake, gastric emptying, glucagon secretion
3- SQ
Bile-acid Sequestrants = (1):
- normally used to lower (2)
- (3) MOA
- (4) route of administration
1- colesevelam
2- lower LDL cholesterol
3- unclear
4- oral
SGLT2 inhibitors = (1):
- (2) normal function of SGLT2, (3) is the net function of (1)
- (4) route of administration
1- canagliflozin
2- Na-glucose co-transported for
glucose reabsorption in the kidney
3- inc glucose excretion –> lower blood glucose
4- oral
Canagliflozin AEs
- inc genital and urinary tract infections
- osmotic diuresis can cause volume depletion / hypotension, inc creatinine, hyperkalemia, hypermagnesemia, hyperphosphatemia,
- contraindicated in Pts with GFR <45