L22- GIT Drugs I (antacids) Flashcards

1
Q

Antacids:

  • (1) definition
  • (2) mechanism
A

1- weak bases (no Rx)

2- Antacid + HCl —> salt + H2O

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Antacid time of onset and duration of action

A

Onset- 5 mins

Duration 1/2-1 hr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

list the classic antacid formulations

A

AlOH, aluminum hydroxide

MgOH, magnesium hydroxide

CaCO3, calcium carbonate (Tums)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Indicate the antacid associated with the following:

  • (1) osmotic diarrhea
  • (2) constipation
  • (3) CO2 causes belching leading to (4)
A

1- MgOH
2- AlOH
Note- MgOH, AlOH can be combined to net no changes in BMs

3- calcium carbonate
4- metabolic acidosis // milk alkali syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

discuss the main adverse effect of antacids

A

Dec absorption of co-administered drugs:

  • includes tetracylcines, fluoroquinolones, itraconazole, iron
  • result of binding / chelation to many drugs
  • inc gastric pH –> alters weakly charged drugs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly