L3 Pt. 2 Flashcards
Chars. Of TCC
- most common form of canine bladder cancer
- most common in trigone
- increased incidence in females, scotties, shelties, and beagles
- uncommon in cats, cattle
- cows that eat bracken fern can get
- assoc. with dysuria, hematuria, pollakiuria, bladder mass on US/rectal
Best sample collection technique to get sample of TCC
traumatic catheterization
- cystoscopy more expensive
- 30% of free catches will have cells
- aspiration can seed abdomen with cancer cells; only perform if owner wants an answer but doesn’t want to treat
Cytological appearance of TCC
- large sheets of cells
- distinct cytoplasmic borders in some cases
- malignant features: large, irregular nucleoli, areas of light and dark, binucleation, nuclear molding, high N:C ratio, anisokaryosis
- can have large cytoplasmic vacuoles filled with pink secretory material (“signet ring”)
Chars. Of benign prostatic hyperplasia
- more common in older intact dogs
- assoc. with uniform enlargement of the prostate
- may or may not be painful
- cytology appears like a uniform sheet of epithelial cells in a honeycomb pattern
Chars. Of prostatic carcinoma
- most common in older dogs >10 yrs
- irregularly enlarged, nodular, firm, painful
- dysuria +/- hematuria may be present
- mineralization common
- locally invasive, but can met to LN, other organs, and axial skeleton
Chars. Of Neuroendocrine neoplasms in general
- tumors of chemoreceptors and endocrine glands (thyroid, parathyroid, endocrine pancreas, adrenal gland, carotid and aortic body)
- exfoliate well
- have free nuclei in background of cytoplasm (fragile cells)
- have uniform populations with minimal atypia - difficult to call malignant
- require histo to call malignant
Chars. Of Canine Thyroid neoplasms
- neuroendocrine tumor
- typical presentation = mass on ventral neck to thoracic inlet
- common in boxers, beagles, goldens
- 90% malignant
- usually not biochemically active/secretory
- locally invasive and will met as they grow bigger
- tx of choice = surgical excision
- thyroid and parathytoid tumors look same, except parathyroid more likely to be hypercalcemic
Cytologic appearance of canine thyroid neoplasms
- uniform pop. Of nuclei in background of cytoplasm
- few distinct cytoplasmic borders
- aspirates may be heavily blood contaminated
- typical neuroendocrine appearance
- colloid (pink) and tyrosine (dk purple/black) granules
Chars. Of feline thyroid neoplasms
- may be cystic or bilateral
- usually benign in cats
- biochemically active (hypersecretion of thyroid hormones)
- adenocarcinomas locally invasive (40-70% met to regional LN)
- adenomas most common, but requires histo to dx
- can cause hyperthyroidism in cats
- look similar to canine
Equine thyroid tumors
- common in horses > 16 yrs
- most benign
- usually nonfunctional
- adenocarcinoma possible
Chars. Of parathyroid neoplasia
- uncommon
- dx relies on lab findings
- majority benign
- adenocarcinomas uncommon
Name 3 urogenital tumors
- Transitional cell carcinoma
- Benign prostatic hyperplasia
- Prostatic adenocarcinoma
Chars. Of transitional cell carcinoma
- most common form of canine bladder cancer
- most commonly in the trigone
- increased incidence in females
- scotties, shelties, and beagles
Chars. Of Endocrine pancreatic neoplasia
- insulinoma (tumor of islet/beta cells)
- overproduces insulin
- most common in large breeds >5yrs, ferrets
- assoc. with hypoglycemia
- can dx. With insulin:glucose ratio
- usually a small lesion that is biologically active
- frequently malignant (mets to LIV, LN)
Cytologic appearance of endocrine pancreatic neoplasia (insulinoma)
- neuroendocrine
- numerous cytoplasmic vacuoles
- usually get samples from imprints from surgery
Chemoreceptor tumors (Paragangliomas) include:
- chemodectomas: aortic body and carotid body tumors
- pheochromocytomas
- most common in dogs
Chars. Of heartbase tumors (aortic body)
- type of chemodectoma (chemoreceptor tumor)
- most common in dogs, esp. Brachys >6 yrs
- usually present with pericardial effusions and CS of R heart failure
- generally slow-growing, multi-lobulated, encapsulated mass
- can be benign or malignant
- if malignant can invade myocardium
- can met to veins or lymphatics
Cytologic appearance of heartbase tumors
- highly cellular
- neuroendocrine
- round nuclei
- degree of anisokaryosis varies
Cortex of adrenal gland produces:
- mineralocorticoids
- glucocorticoids
- adrenal androgens
Medulla of adrenal gland produces:
- catecholamines
- epinephrine
- norepinephrine
Functional adenoma/adenocarcinoma –>
Hyperadrenocorticism and/or hyperaldosteronism (cats)
Chars. Of adrenocortical tumors
- primarily in the dog or ferret
- causes CS of hyperadrenocorticism due to hypersecretion of corticosteroids
- adenomas surgically resectable
- adenocarcinomas locally invasive to veins, LIV
Cytologic appearance of adrenocortical tumors
- neuroendocrine
- dense, cytoplasmic vacuolization
- degree of anaplasia depends on adenoma vs. adenocarcinoma
Chars. Of Pheochromocytoma
- tumor of adrenal medulla chromaffin cells
- produces catecholamines
- can be benign or malignant
- rare tumor
- older dogs
- up to 50% incidental finding
- 50% asymptomatic
- can locally invade CVC or met to LIV, LU
- 50% occurence of concurrent neoplasms
- > 10% have concurrent hyperadrenocorticism
Cytologic appearance of pheochromocytoma
- neuroendocrine
- variable degrees of anaplasia
- may see multinucleated cells