[L3 Anatomy and Physiology] Section 2: The musculoskeletal system Flashcards
Explain the cellular structure order of skeletal muscle, starting from the Epimysium.
Epimysium, Perimysium, Fasculi, Endomysium, Muscle Fibres, Myofibril, Myofilaments (actin/myosin).
What is the Epimysium?
The tough membrane that surrounds the whole muscle belly and holds the smaller fasciculi
units together.
What is the Perimysium?
The membrane which surrounds the bundles of muscle fibres (the fasciculi).
What is the Endomysium?
The membrane that surrounds the individual muscle fibres, which contain the myofibrils.
What is a Tendon?
Tough, inelastic fibres which wrap around the end of the muscle and attach it to the outer layer
of the bone.
What is the Myofibril?
The smallest unit, or fibril, within the individual muscle fibers.
What is the Myofilaments?
The contractile proteins myosin and actin arranged within compartments in the myofibril
called sarcomeres.
The power to drive the myosin head in the sliding filament theory is what molecule?
ATP.
How does the ATP molecule prime the myosin for activity?
By binding and transferring energy with the head.
Although the myosin head may have been primed with energy from the ATP, it will be unable to bind with the
actin without the presence of what element in the body and why?
Calcium - In a relaxed state, the myosin-binding sites on the actin are blocked by a combination of other molecules (troponin and tropomyosin) and Calcium causes the blocking molecule to move away from the myosin binding site (thus allowing the
‘primed’ myosin head to bind with the actin)
What are some structural features of slow twitch/type 1 muscle fibres?
- Smaller diameter fibre size
- Large myoglobin content
- Many mitochondria (cells where aerobic energy is produced)
- Many capillaries to deliver blood and oxygen
- Red in colour
What are some functional features of slow twitch/type 1 muscle fibres?
- Increased oxygen delivery
- Produce less force
- Long-term contractions
- Resistant to fatigue
- Aerobic
What are some structural features of fast twitch/type 2 muscle fibres?
- Larger diameter fibre size
- Smaller myoglobin content
- Fewer mitochondria
- Fewer capillaries
- White (pale) in colour
What are some functional features of fast twitch/type 2 muscle fibres?
Decreased oxygen delivery • Produce more force • Short-term contractions • Less resistant to fatigue • Anaerobic
Explain the four main stages of the sliding filament theory.
COCKING PHASE:ATP is broken down, releasing energy to prime the myosin head into a ‘cocked’ position.
BINDING PHASE: Calcium ions are released from the SR and allow the myosin head to attach to the actin binding sites.
POWER STROKE: The myosin head rotates, pulling the actin towards the centre of the sarcomere to generate tension/muscle contraction.
RE-SETTING: ATP binds to the myosin head, releasing it from the actin binding site.
What are some effects aerobic/endurance exercise has on Type 1 and Type 2a/2b muscle fibres.
Type I or type IIa fibre changes: • Improved efficiency and work capacity. • Increased number and size of mitochondria. • Hypertrophy. • Increased aerobic enzyme levels. • Increased capillary density.
No change to type IIb fibres.
What are some effects anaerobic, heavy resistance exercise has on Type 1 and Type 2a/2b muscle fibres.
Type IIa and IIb fibre changes: • Increase in anaerobic enzyme levels. • Increased phosphocreatine stores. • Hypertrophy. • Increased contractile protein density.
No change to type I fibres except hypertrophy.
What is the frontal plane?
A vertical plane that divides the body into anterior
and posterior parts.
What is the saggital plane?
A vertical plane that divides the body into left and
right parts.
What is the transverse plane?
A horizontal cross-section through the body which
separates the upper and lower body
What is an axis, and at what angle is the axis of each plane associated with.
A theoretical point around which rotation occurs passes through each plane at right angles.
Which axis passes through the frontal plane?
The anterior-posterior axis