L27 Mouth cancer: epidemiology and aetiology Flashcards
What are the most frequent sites of mouth cancer?
List some head and neck cancers.
- Skin
- Nose and sinuses
- Nasopharynx
- Oropharynx
- Oral cavity
- Pharynx
- Larynx
- Associated bone
What malignant diseases affect skin and mucosa?
Skin:
- SCC
- BCC
- Malignant melanoma
Mucosa:
- SCC
- Soft tissue sarcomas (fibrosarcoma, liposarcoma)
- Malignant lymphoma
Describe the epidemiology of mouth cancer.
- Relatively rare
- Twice as common in men
- 2386 deaths in the UK in 2014
- Predominantly a disease of the elderly but in recent years has become more common in younger people
What is the most common oral malignant neoplasm?
Squamous cell carcinoma (accounts for more than 90% of oral malignant neoplasms)
What is the 10 year survival rate for intra-oral SCC?
- 19-59%
- Poor prognosis
What is the average size of intraoral SCC ar presentation?
3-4cm (large)
Where is mouth cancer more common?
More common in India.
How does social class relate to mouth cancer?
- Oral cancer 3 times more common in social class V (most depriveed) than social class I
Name some aetiological factors for mouth cancer.
- Tobacco
- Alcohol
- UV light (lip cancer)
- Betel chewing
- Infection
- Irradiation
- Diet and nutrition
- Dental factors
- Immunosuppression
- Occupation
Explain how tobacco is a risk factor for mouth cancer.
- Over 90% of patients with oral cancer use tobacco in some form
- Pipes, cigars cigarettes
- Reverse smoking
- Oral tobacco products (snuff/snus) were banned in the UK in 1992
Explain how betel chewing is a risk factor for mouth cancer.
- Areca nut wrapped in betel leaf with added tobacco
- Users develop leukoplakia
- Can also develop submucous fibrosis (mottled, marbled, thick mucosa)
- Carcinoma develops in area of leukoplakia
Explain how alcohol is a risk factor for mouth cancer.
- 75-80% of pts frequently consume alcohol
- Dose/time relationship
- Drinking+smoking = highest risk
- Carcinogens found in distilled spirits (vodka, gin, rum, tequila, whiskey)
- Alcohol increases permeability of oral mucosa
What infections are risk factors for mouth cancer?
- Viral infection: Herpes simplex, HPV, EBV, HIV
- Candida
- Syphilis
Explain how HPV is a risk factor for mouth cancer.
- HPV related oropharyngeal cancer commonly affects tonsils, base of tongue and soft palate
- Associated with HPV-16 and -18
- Affects a younger age group
- Significant increase over the past decade
- Significantly better prognosis for HPV positive pts (up to 80% 5-year survival rate) than tonsillar cancer in non-HPV related cases
- More sensitive to chemo and radiotherapy than SCC