L26 - Thermoregulation 1 Flashcards

1
Q

At what temperature are proteins denatured?

A

41˚C

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2
Q

At what body temperature will a person die?

A

43˚C

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3
Q

At what temperature will all cells in the body die?

A

50˚C

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4
Q

At what temperature do you start to “feel cold” when nude?

A

25˚C, initiating a physiological response

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5
Q

Above which temperature are you safe while wearing light clothing?

A

0˚C

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6
Q

Above which temperature are you safe while properly clothed?

A

-29˚C

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7
Q

At which temperature does the respiratory tract begin to freeze?

A

-50˚C

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8
Q

Which structures/processes must be involved in thermoregulation?

A

ANS, skin, motor cortex, hypothalamus, renin angiotensin aldosterone system, ANP, vasopressin, cardiovascular system, respiratory system

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9
Q

What are the two types of regulation that thermoregulation requires?

A

autonomic regulation and behavioural regulation

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10
Q

What does autonomic regulation involve?

A

redistribution of blood (CVS), perspiration, fluid balance (renal and endocrine), metabolic changes (respiratory system), non-voluntary skeletal muscle effects

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11
Q

What does behavioural regulation involve?

A

changing environment, altering clothing, adjusting fluid/food intake, skeletal muscle effects

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12
Q

What is core temperature?

A

temperature inside the chest, abdomen and brain

maintained at ~37˚C ± 0.5˚C

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13
Q

What is the normal core temperature range?

A

35.5 - 37.7˚C

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14
Q

What is peripheral (shell) temperature?

A

can vary broadly
skin temperature varies with environment
working muscles during exercise may reach 41˚C

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15
Q

What is the physiological aim of the body in regards to body temperature?

A

maintain a stable core temperature, especially in the brain

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16
Q

What temperature results in hypothermia? What about hyperthermia and heatstroke?

A

<35˚C

>40˚C, >42˚C

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17
Q

What are the two main classes of thermoreceptors?

A

central thermoreceptors and peripheral thermoreceptors

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18
Q

Where are central thermoreceptors located and what is their role?

A

anterior hypothalamus

detect temperature changes in the blood

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19
Q

Where are peripheral thermoreceptors located and what is their role?

A

located in the skin and viscera
report to central thermoreceptors
can produce local effects

20
Q

What are the four main subclasses of peripheral thermoreceptor?

A

warm and cold receptors

cold pain and heat pain receptors

21
Q

What are central thermoreceptors physically connected to in the hypothalamus?

A

the thermoregulatory center which indirectly sends out autonomic signals through the ANS to skin arterioles, skeletal muscle and sweat glands in order to maintain core body temperature

22
Q

How is heat generated?

A

internally: metabolism, heat released during muscle contractions
externally: heat input if environmental temperature exceeds body temp

23
Q

How is heat lost?

A

environmental heat loss: radiation, conduction, convection and evaporation

24
Q

What is heat?

A

heat = kinetic energy (momentum) of particles

moves from hotter objects to colder objects

25
Q

What is conduction?

A

transfer of heat from one object to another via direct contact

26
Q

What does it mean if a material is better at transferring heat than other materials?

A

this material is a conductor

opposite is an insulator

27
Q

What is radiation?

A

electromagnetic radiation generated by thermal motion of charged particles

28
Q

What is convection?

A

hot air rises and cold air sinks, thus heat can be “carried away” from the body’s surface

29
Q

What is evaporation?

A

conversion of water from liquid to gas by using energy

at body temperature, 2400 calories are required to evaporate 1ml of water

30
Q

How much heat loss is accounted for by radiation?

A

~60% of heat loss

31
Q

How much heat loss is accounted for by conduction and convection?

A

~20% of heat loss

increased with wind

32
Q

How much heat loss is accounted for by evaporation?

A

not necessary <32˚C

33
Q

How is heat loss maximised by the body?

A

increasing cutaneous blood flow and increase sweating (if necessary)

34
Q

How is cutaneous blood flow increased?

A

under control of hypothalamic thermoregulatory centre
sympathetic cholinergic neurons dilate cutaneous blood vessels
↑ blood flow to skin means cardiac output must ↑ to maintain BP (HR + SV ↑)

35
Q

How is sweating increased? How does sweating maximise heat loss?

A

sweat production activated by sympathetic cholinergic neurons
cooling by evaporation: enhanced by ↑ air flow, inhibited by humidity
can increase heat loss ~20 fold

36
Q

What would happen to ventilation (at rest) when body temperature rises?

A

increase
this is because as temperature ↑, enzymatic activity ↑ as well resulting in ↑ metabolism and therefore ↑ requirement for O2 ∴ ventilation ↑

37
Q

What are some behavioural adaptations to increasing heat loss?

A

seek shade, wearing loose/light clothing, inactivity, decreasing food intake, eating food with high water content (becomes more appealing)

38
Q

What is heat syncope? What is “prickly” heat?

A

excessive blood diverted to skin reduces blood flow to brain

inflammation of sweat glands - itchy “pimply” rash

39
Q

What is heat exhaustion?

A
moderate hyperthermia (core temp 37˚C - 40˚C)
dizziness, fatigue, nausea, possible collapse
40
Q

What is heatstroke?

A

severe hyperthermia (core temp >40˚C)
common during heat waves and in athletes
kills more Australians than all other natural hazards combined

41
Q

Which characteristics would be anatomically advantageous for maintaining a low body temperature in the heat?

A

long, lean extremities, a high surface-area-to-volume ratio and thick hair only on regions facing the sun

42
Q

How do long, lean extremities increase heat loss?

A

increase surface-area-to-volume ratio and increases conduction/radiation hence heat loss

43
Q

Why is an insulating fat layer which is consolidated to one area beneficial to heat loss?

A

allows more heat loss from extremities

also to put it simply there is insulation from heat of sun

44
Q

Which characteristics would be anatomically advantageous for maintaining a high body temperature in the cold?

A

low surface-area-to-volume ratio reduces heat loss

subcutaneous fat evenly distributed as insulation to retain heat

45
Q

How have humans evolved to different climates?

A

humans evolved primarily in an African climate, however, some anatomical adaptations have evolved between races based on climate (environmental) differences