L26- Eicosanoids (#8)

Question 1

What is an eicosanoid?

Answer 1

Signaling molecules dervied from 20-c unsaturated EFA

Question 2

What 4 things do eicosanoids include?

Answer 2

Prostaglandins, Throboxanes, Leukotrienes, Epoxides

Question 3

What are prostaglandins, prostacyclin, and thromboxanes collectively referred to as?

Answer 3

Prostanoids

Question 4

____ is a prostaglandin with an extra ring?

Answer 4

PGI2 (prostacyclin)

Question 5

The eicosanoid, Prostanoids is produced in what?

Answer 5

Most cells

Question 6

The eicosanoid, leukotrienes, is produced where?

Answer 6

In leukocytes

Question 7

Epoxides, the eicosanoid, is produced in?

Answer 7

Macrophages

Question 8

What are the 2-letter abbreviations for prostaglandin, thromboxane, and leukotriene?

Answer 8

Prostaglandin- PG
Thromboxane- TX
Leukotriene- LT

Question 9

What does the third letter in the eicosanoid nomenclature represent?

Answer 9

Components of ring on prostaglandin

Question 10

What does the number on the eicosanoid nomenclature refer to?

Answer 10

Series (denotes # double bonds in linear poriton of the molecule (1,2,3))

Question 11

In the diet, LNA w3 and LA w6 can serve as ___ for eicosanoid synthesis

Answer 11

Precurors

Question 12

In the animal, LNA is metabolized to what fatty acid?

Answer 12

EPA (eicosapentaenoic acid)

Question 13

In the animal, LA is metabolized to possibly what 2 fatty acids?

Answer 13

AA (arachidonic acid)* or DGLA (dihomo y-linolenic acid)

Question 14

Unlike dogs, cats have a recommended dietary intake of arachidonic acid, as they express only low levels of a key enzyme that is necessary for ______ acid synthesis

Answer 14

Arachidonic

Question 15

AA, EPA or DGLA can be hydrolyzed from ___________________ used to synthesize eicosanoids

Answer 15

plasma membrane phospholipids