L22 Antihistamines Flashcards
1
Q
Define a local hormone
A
A chemical messenger formed by tissues on which it acts
2
Q
If not stored what happens to histamine?
A
It is rapidly deactivated by amine oxidase
3
Q
Where is histamine released from?
A
Mast cells
4
Q
What happens during the arousal pathway?
A
There are histaminergic neurones in the TMN
They become spontaneously active and release histamine during wakefulness
5
Q
What happens at the emetic centre?
A
The histaminergic neurones in the TMN receive input from the vestibular centre in the inner ear and other sensory inputs
6
Q
What happens at the emetic centre is the inputs are mismatched?
A
Histaminergic neurones are activated
Emetic centre in medulla is activated
