L21: Shock Flashcards
What is the main controller of arterial blood pressure?
Cardiac output and total peripheral resistance
MAP= CO x TPR
Or
MAP= Diastolic pressure +1/3 pulse pressure
Or
MAP= 1/3 systolic + 2/3 diastolic
How do you calculate the cardiac output?
CO= SV x HR
How do you calculate pulse pressure?
Systolic pressure- diastolic pressure
What is haemodynamic shock?
Acute condition of inadequate blood flow throughout the body
Catastrophic fall in MAP–> circulatory shock
Insufficient perfusion of tissues/organs–> brain, kidneys, heart
What can cause shock?
Fall in CO
Fall in TPR beyond capacity of heart to cope
What can cause the CO to fall?
Mechanical –> ventricle cannot fill properly –> obstructive
Cardiogenic–> ventricle cannot empty properly –> pump failure
Hypovolaemic–> Reduced blood volume leads to poor venous return
What can cause cardiogenic shock?
Pump failure–> unable to maintain CO
- MI–> Damage to LV–> necrosis of tissue unable to contract and pump blood out properly
- Serious arrhythmias–> heart block, bradycardia or tachycardia (HR too fast, ventricles cannot fill properly so reduced CO)
- Acute worsening of HF–> if HF suddenly gets worse MAP pressure can suddenly decrease and lead to shock
What is the main prinicple behind cardiogenic shock?
Heart fills properly
Fails to pump it out effectively
CVP maybe raised or normal
–> raised due to back pressure, if heart doesn’t empty (ESP high), less can enter to fill it
Tissue poorly profused
–> coronary arteries–> worsens the problem
–> kidneys poorly perfused–> oligouria
What is cardiac arrest?
Lack on consciousness with lack of pulse
Heart stopped or has ceased to pump effectively
What can cause cardiac arrest?
- Asystole–> loss of electrical and mechanical activity
- -> heart stopped–> No CO–> shock - Pulseless electrical activity–> Electrical activity but no pulse, dissociation between electrical activity and mechanical activity, extreme hypovolaemia (blood loss), cardiac temponade, fast ventricular tachycardia
- Ventricular fibrillation–> uncoordinated activity
How does ventricular fibrillation lead to cardiac arrest?
Ventricular fibrillation usually follows MI or electrolyte imbalance or arrhythmias
Ventricular fibrillation–> heart unable to fill properly or eject blood properly reduced CO–> cardiac arrest
How is Cardiac arrest managed?
Basic life support
–> chest compression and external ventillation
Advance life support
–> defibrillation
–> electric current delivered to the heart
–> depolarises all the cells- puts them in the refractory period
–> allows coordinated electrical activity to restart
Adrenaline
–> enhances myocardial function
–> Increases peripheral resistance
What is cardiac temponade?
Compression of the heart
- -> blood or fluid fills up in pericardial space
- -> restricts filling of the heart–> limits end diastolic volume
- -> affects both left and right side of heart
What does cardiac temponade result in?
Increase CVP–> unable to fill properly
Low arterial BP–> less blood to pump out
Increase HR in attempt to compensate–> ↓ SV–> ↓ CO
How can a pulmonary embolism cause mechanical failure?
PE in pulmonary artery Pulmonary artery pressure is high Limited output from right ventricle Central venous pressure high Reduces blood return to left atrium and ventricle Reduced output from left ventricle Low arterial blood pressure Arterial blood pressure low Shock Chest pain, dyspnoea (difficulty breathing)