L20 - Endocytosis Flashcards
1
Q
What is phagocytosis?
A
The uptake of large particles by phagocytes.
2
Q
One endocyctic pathway is Macropinocytosis. How does this work?
A
°Cells form actin driven ruffles which sometimes fuse to form macropinosomes
°Mechanistically similar to phagocytosis
°Non selective uptake of extracellular material
°Used by cancer cells to take up nutrients
3
Q
What is Clathrin-mediated endocytosis?
A
Clathrin coated pits and vesicles
Clathrin triskelia polymerise into lattices
Dynamin is required to pinch off clathrin coated vesicles