L2 what is Pharmacology Flashcards
Pharmacodynamics
what the drug does to the body
Pharmacokinetics
what the body does to the drug
Pharmacokinetics A.D.M.E
A-absorption (How does it get in)
D-distribution (Where does it go)
M-metabolism (How is it broken down)
E-excretion (How does it leave)
Potency
the strength of something such as a drug or alcoholic beverage.
Efficacy
the ability to produce a desired or intended result
Potency vs Efficacy
potency: amount of drug necessary to produce desired effect
efficacy: ability of drug to achieve desired effect
Drug selectivity
a drug is selective if it affects only one type of cell or tissue and produces a specific physiologic response
Adverse side effects
Harmful or undesirable effect of a medication or intervention
Concentration response
Relationship exists between the concentration of a drug at its site of action and its therapeutic or toxic effects.
Just because a drug is in the system doesn’t mean it’s enough to be therapeutic– drug level needs to reach a certain concentration to be therapeutic
dose response
correlation between the amount of a drug given and its effects
Drug half life
the time required for the elimination process to reduce the concentration of the drug to 50% what it was at initial administration
Drug Agonist
a drug that will bind to a receptor on a cell and trigger a response by the cell, generally mimicking the response or action of a naturally occurring substance
Drug Antagonist
a drug that blocks another drug from combining with a receptor
Therapeutic Index
A ration of the blood concentration at which a drug causes death (in animal) or toxicity (human) to the amount that causes a therapeutic effect.
Drug target
- Receptors
- Ion channels
- Enzymes
- Carrier Molecules
