L14 Intro to toxicology Flashcards
Toxicology
The study of the adverse effects of chemical, physical, or biological agents on living
organisms and the ecosystem
Toxicant
Substance that produces an adverse biological effect.
Includes chemical, physical and biological forms. (drugs, radioactive material and venoms)
Toxicity
Degree at which a toxicant produces harmful effects.
Toxicity factors (not influence)
Route
acute vs chronic
target organ tox vs systemic tox
4 key factors that influence toxicity
Magnitude of exposure (i.e., “dose”)
* dose-response relationship is fundamental
Route and site of exposure
* inhalation / ingestion / topical / parenteral
Duration and frequency of exposure
* acute / subacute / subchronic / chronic
Latency of toxic response
* immediate or delayed effect (e.g., in utero exposure)
Toxic causality
toxicant has induced the observed effects
NOAEL
no adverse effect level
TD50
the dose at which half of the individuals show response
dose required to produce a particular toxic effect in 50% of animals
Dose-response relationship toxicology: slope of curve
the rate at which toxic effects builds up
The distribution of responses to a given dose of toxicant within a population resembles a ___ curve
bell-shaped
In a bell shaped curve for toxicity responses what are some characteristics of the curve
Most ppl will response similarly being the majority of the curve (middle major).
However, a small proportion will show servere responses (susceptible) or mild responses. (res)
deviation from dose-response relationships - individuals can display high susceptibility to toxicants. Why do some people deviate?
- idiosyncratic responses
- genetic factor(s)→ abnormal response or metabolism change.
- hypersensitivity (involve immune response)
LD50 (lethal dose, 50%)
the amount of toxicant required in one single dose to kill half of the test population; (mg/kg)
Small LD50 means
Greater toxicity as smaller dose can kill half the test population.
Large LD50 means
Less toxicity as a bigger dose is needed to kill half the test population.