L2- New concepts in HIV pathogenesis

Question 1

How does infection start?

Answer 1

Slide 4-5

Question 2

What biological factors influence transmission?

Answer 2

Slide 6

Question 3

Discuss immune activation as a correlate of progression.

Answer 3

Slide 8

Question 4

What is the immunopathogenesis of HIV-1 and SIV infection?

Answer 4

Slide 9

Question 5

What are the characteristics of Elite controllers and rapid progressors? What is the paradox of naturally infected monkeys?

Answer 5

Slide 10-11

Question 6

What is the major site of acute viral replication and CD4 T cell death?

Answer 6

-GALT

Slide 13-14

Question 7

Describe the microbial translocation model.

Answer 7

Slide 16

Question 8

What are the consequences of GALT damage?

Answer 8

Slide 17

Question 9

What is the vicious cycle of immune activation?

Answer 9

Slide 18

Question 10

What are some other mechanisms of CD4+ T cell loss?

Answer 10

Slide 19-22

Question 11

Discuss the immune system collapse in AIDS

Answer 11

Slide 23

Question 12

When are viral reservoirs established?

Answer 12

Slide 25

Question 13

What effect does ART have on HIV-1 and why?

Answer 13

Slide 26-27

Question 14

What is a potential cure for HIV-1?

Answer 14

Slide 28