L2- Lifecycle and pathogenesis of (+)RNA viruses

Question 1

What is the immune response to viral infection?

Answer 1

Slide 3

Question 2

Describe beta-coronaviruses

Answer 2

Slide 4

Question 3

What is the route of infection of SARS-CoV-2? What is its infectious cycle

Answer 3

Slide 5-6

Question 4

How are viral RNAs recognised by PRRs?

Answer 4

Slide 7

Question 5

What are the innate immune pathways activated during SARS-Cov-2 infection?

Answer 5

Slide 8

Question 6

How can you screen to identify restriction factors of SARS-Cov-2 infection? What are some of these factors?

Answer 6

Slide 9-10

Question 7

What is the adaptive immune response to SARS-Cov-2?

Answer 7

Slide 11

Question 8

What is the SARS-Cov-2 induced immunopathology? What about in critical cases?

Answer 8

Slide 12-13

Question 9

Discuss the global burden, tropism, target cells and pathogenesis of the flaviviruses, Dengue and Zika.

Answer 9

Slide 14

Question 10

Discuss the structure, life cycle and infection of flaviviruses.

Answer 10

Slide 15-19

Question 11

Describe the initiation of immune responses at the skin. What leads to systemic infection?

Answer 11

Slide 20-21

Question 12

Describe the antibody-dependent pathologies during dengue virus infections.

Answer 12

Slide 22

Question 13

Discuss the distinct immune signatures in SARS-Cov-2 vs Zika/Dengue infection.

Answer 13

Slide 23-24

Question 14

Discuss how SARS-Cov-2 deregulates the immune system.

Answer 14

Slide 25-27

Question 15

What are the possible vaccine platforms for SARS-Cov-2?

Answer 15

Slide 28

Question 16

What are the possible vaccine platforms for Dengue?

Answer 16

Slide 29