L2 C2: Aminoglycosides

Question 1

Mnemonic for Aminoglycosides?

Answer 1

“A Mean Old Mycin”

Used to treat serious, resistant, life threatening, gram negative infx

Question 2

ALL aminoglycosides end in Mycin, but not all DRUGS ending with mycin are amino glycosides. Such as those who have “____” in the middle of their name

Answer 2

“THRO”

Azithromycin, Clarithromycin, Erythromycin. All have THRO in the middle. So, THRO them off the “Mean Old Mycin” list

Question 3

What are toxic effects?

• Mycin—Sounds like Mice (Think _____) = Monitor____

• The human ears are shaped like a _____ so another toxic effect of
is _______= monitor _____

Answer 3

ears (Ototoxic) = hearing (#1), balance, tinnitus
(ringing of the ear, CN8 toxicity)

Kidney, nephrotoxicity = Creatinine

Question 4

1. Best indicator of kidney function?
2. What is better than Serum creatinine?

Answer 4

Creatinine

24-hour creatinine clearance

Question 5

figure 8 drawn inside the ear should remind you of of 2 things:

They are toxic to _____ (which CN?)
Administer them ____ (how often) via_____ (route)

Answer 5

CN 8

Q8, IM/IV

Question 6

Do not give Mean Old Mycins _____ (route) because they are not absorbed, and therefore would not have any ______ effects

Answer 6

PO

systemic

Question 7

2 cases where Mean Old Mycins are given PO?

________ encephalopathy (or ______ coma): ammonia level gets too high

2. Pre-op ______ surgery: to sterilize before surgery

Answer 7

1. Hepatic encephalopathy (or hepatic coma): ammonia level gets too high
2. Pre-op bowel surgery: to sterilize the bowel before surgery

• In both cases, the ABX stays in the gut (not absorbed), sterilizes the bowel, and would not be toxic

Question 8

Oral mycin Drugs? (Neo Kan)

Answer 8

Neomycin and Kanamycin

Question 9

Both Through & Peak are dependent on the _____

Answer 9

Route

Question 10

For THROUGH, it is ALWAYS drawn ___ min ____ (after/before) the next dose

Answer 10

30 min; BFORE

Question 11

For PEAK SubL:
______ min after drug _____

Answer 11

5-10 min; dissolved

Question 12

For PEAK IV:
______ min after drug is _____

Answer 12

15-30 min; finished (bag is empty)

Question 13

For PEAK IM:
______ min after

Answer 13

30-60 min

Question 14

For PEAK SQ?

Answer 14

depends on insulin

Question 15

You give 100ml of a drug at 200 ml (the drug takes 30 min to run). If you hang the drug at 10am, it will finish running at 10:30am. When will the drug peak?

a. 10:15 AM
b. 10:30 AM
c. 10:45 AM
d. 11:00 AM

Answer 15

D

Always pick the highest option without going over the range