L19 - Ion channels

Question 1

List one mechanical-gated ion channel?

Answer 1

TRPV4

Question 2

K+ channels are most diverse, > 65 clones

• Voltage gated
• Ca2+ activated
• Inward rectifiers
• Leak or background channels

Answer 2

K+ channels are most diverse, > 65 clones

• Voltage gated
• Ca2+ activated
• Inward rectifiers
• Leak or background channels

Question 3

Decreased AP freq for are seen in which diseases

Answer 3

MS and cognition disorders

Question 4

Increased AP freq for are seen in which diseases

Answer 4

Seizures, pain, ADHD, anxiety, bipolar and schizophrenia

Question 5

Alcohol is able to enhance a subtype of K+ channel’s opening - leading to depressing response

Answer 5

Alcohol is able to enhance a subtype of K+ channel’s opening - leading to depressing response

Question 6

GRK2 can bind the _ subunit and desensitize the Kir (Potassium Inward Rectifier) channels

Answer 6

Beta gamma

Question 7

Kir _ to _ activation leads to?

Answer 7

3.1 to 3.5 activation decreases neuronal excitability

Question 8

Ca v and exocytosis - which channels are involved?

Answer 8

Ca v 2.1 (P/Q) and Ca v 2.2 (N)

Question 9

Difference between opening time in L, T, P/Q N R types of Ca2+ channels?

Answer 9

L type = opens for longer period (role in vascular contraction and cardiac contractility)

T type = transient, opens for shorter period

P/Q, N, R type - rapid and not as open for long (involved in neuronal activity)

Question 10

NicR on presynaptic terminals lead to an increase in?

Answer 10

Ca2+ in the presynaptic terminal (alpha 7 homomers are highly Ca2+ permeable) and enhance the release of the NT