L16: Intestinal nematodes Flashcards

1
Q

Name general characteristics of nematodes

A

long, cylindrical, unsegmented bilately, symsttry, covered by cuticle

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1
Q

Describe the face of nematodes

A
  1. pseudocoelomates with body cavity
  2. no suckers/hooks/respiratory/circulatory
  3. male smaller than female
  4. nematode infection impact human/animal health a lot very important
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2
Q

What is the body wall made of

A

outer cuticle, hypodermis, somatic musculature

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3
Q

Go in depth about quantites of body wall

A
  1. cutile
    *covers whole body and lines cavity, recturm, vagina and pore
    *has metabolically active enzymes
    *smooth with spines, ridges for locomotion
    *molted and reformed 4 times in life
  2. hypodermis to secrete cuticle
  3. somatic musculature with longi muscles arranged in > 1 rows with different shapes

has 2 muscle regions
contactical with myofibrils and non contracile to hold organelles

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4
Q

What are the layer of cutiicl

A

It consists of 4 basic layers
i. Epicuticle
ii. Exocuticle
iii. Mesocuticle
iv. Endocuticle

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5
Q

What is the digestive tract of nematodes made of

A

have compelte digestive tract

foregut: for digestion, mouth, phyraniz, esophogous

midgut: intestine, sight of absoroption with microvilli and digestion

hingut: in females it has recturm and anus in males it has reprodutive parts

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6
Q

What does the nervous system of nemotodes consit of

A

circumesophageal commissure – also called the nerve ring, surrounds the esophagus

Rectal commissure – encircles the rectum

Longitudinal nerve trunks from the nerve ring extends the length of the nematode and peripheral nerves
branch from here to supply sensory organs

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7
Q

What is the exretory system of nematodes

A

1 or 2 renettes

digestive tract is the principal excretory organ, so this is only osmoregulatory

no flame cells

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8
Q

Desrcibe reproctuve system of nematodes

A

seperate sexes => diosecious
tubular organs lysin in pseudocoelom

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9
Q

Detail the male reproductive system of nematodes

A

posterio end is curved
structures exten to cloacoa
single testis
1 or more copulatory spicules to keepvulva open
spicule guide

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10
Q

Detail male reproductive system of female

A

didelphic with 2 ovaries and 2 uteri
single vagina and vulva

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11
Q

Life cycle of Nematodes

A

Sexual reproduction occurs within an infected definitive host
* Typically includes 6 stages – egg, 4 juvenile larval stages and adult
* Infectious stages for humans and animals are either the egg or larva
* Eggs only hatch under specific, favorable external conditions to protect the larva
* Larval stages are separated by rounds of molting

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12
Q

Molting nematodes general characteristics

A

nematodes go trough 4 rounds of molting or excheatment

during the process it forms a new cuticle, loosens the old one, reaptures to break out of the old one and escapes the larva

controlled by exsheating fluid

host and site specific

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13
Q

Enterobius vermicularis

A

def host: humans
int host: none

causes enteribasis

worldwide, common in temperate places

kids, overcrowded

most common in N.aermica

whip shape, females have pointed tail = pinworm

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14
Q

Life Cycle of Enterobius vermicularis

A
  1. Gravid adult female worms deposit eggs on perianal folds
  2. Infection occurs via autoinfection (transferring eggs to the mouth with
    hands after scratching the perianal area) OR retroinfection by L3
    larvae
    that hatch from perianally located eggs and migrate back up the host’s
    GIT OR cross-infection (exposure to eggs in the environment e.g.,
    contaminated surfaces, clothes, bed linens, infected persons etc.) OR
    inhalation of airborne eggs
  3. Following ingestion of infective eggs, larvae hatch in the small intestine
  4. The adults establish themselves in the colon, usually in the cecum
  5. Gravid females migrate nocturnally outside the anus and oviposit while
    crawling on the perianal skin. Females lay up to 15,000 eggs daily
    Larvae inside the eggs develop (become infective) in 4-6 hours under optimal
    conditions. Eggs can remain viable for up to 20 days in a moist environment
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15
Q

Clinical Presentation of Enterobiasis

A

asymptio

heavy infection => perianal prutirus at night => bacterial superinfection/excoriations => scratchy butt eggs to finger nails infection

16
Q

Diagnosis of Enterobiasis

A

eggs around perianal area during scotch test

17
Q

treatment of enterobiasis

A

mebendazole, alternatively, albendazole but only for adults

18
Q

What is Trichuris trichiura

A

def host: humans
int host: no body

soil transmitted helminth and tricharis

worldwide but tropic/subtropic - moist is good for embryonic

3rd most common worm

19
Q

Trichuris trichiura general characteristics

A

whip worm, females longer than males

T.campanula cat

T. suis pig

20
Q

Life Cycle of Trichuris trichiura

A
  1. The unembryonated eggs are passed with the stool
  2. In warm, moist soil, the eggs develop into a 2-cell stage
  3. This is followed by development into an advanced cleavage stage
  4. Finally, an embryonated egg develops with an L3 stage larva Eggs
    become infective 15-30 days after being passed
  5. After ingestion of infective (embryonated) eggs in soil-contaminated
    hands or food, eggs hatch in the small intestine and release larvae
  6. Larvae mature and establish themselves as adults in the colon. The
    anterior portion of the worm is ‘threaded’ into the mucosa of the
    cecum and ascending colon where the worm resides. Female worms
    shed 3000-20000 eggs per day. Adult worms have a life span of about
    1 yea
21
Q

Clinical Presentation of Trichuriasis

A

light is asymptomic

chronic = rectol prolapse
go to colon and rectum => inflammation which cause tenemus and prolapse

gastro issues

anemia, weight loss

22
Q

Which infections happen together often

A

E. histolytics and Trichuriasis

23
Q

What is Ascaris lumbricoides, small on general characteristics

A

def host: human
int host: none

soil transmitted helminth

adutl causes ascaris and larvae causes pneumonia

worldwide, common in tropic / subtropics

adults are largest nematode parasite = large roundworms

3 lips lines with teeth

24
Q

Life Cycle of Ascaris lumbricoides

A
  1. The adult worms live in the lumen of the small intestine.
  2. A female may produce ~200,000 eggs daily. These are passed with the feces
  3. The unfertilized eggs may be ingested but are not infective. Larvae develop to
    infectivity within fertile eggs after 18 days to several weeks, depending on the
    optimum environmental conditions – moisture, warmth, shaded soil, oxygen
    levels
  4. The Infective (embryonated) eggs are swallowed
  5. The larvae hatch in the duodenum
  6. Larvae then invade the intestinal mucosa, enter the circulatory system, and
    over the period of one week, are carried to the heart and then the lungs
  7. Larvae mature further in the lungs (10-14 days), penetrate the alveolar walls,
    and ascend the bronchial tree to the throat. Coughed up larvae are swallowed.
    Upon reaching the small intestine, they develop into adult worms. About 3
    months after initial ingestion of infective eggs, adult worms begin to oviposit.
    Adult worms can live for 1-2 years
25
Q

Clinical presentation of Ascariasis

A

85% asympto

more eggs => worse, malnutrion
break down the phases:

pulmonary migration phage
*inflammatroy and hypersensitive, penumonia sympmtoms, eosinophila, urticaria

developing mature in intestinse
abdmonidal pain, nausea, vomitting, impaired absoroptn

heavy infection
*intestinal abstroction, liver absecces, appendecitis

26
Q

Diagnosis of STH Infections

A

T. Trichiura
*eggs in poop, heavy infection diagnosis, rectal prolapse using protpscope

A. lumbricoides
*eggs in poop, eggs expelled by butt or mouth
*larvae in spetum/gastric aspirate in pulomanry migration

27
Q

Treatment of STH Infections

A

Albendazole or mebendazole
Drugs target adult worms only