L14 - Brain Development & Cancer

Question 1

How is the LTP maintained

Answer 1

altered transcription

epigenetic modifications

Question 2

CREB activation leads to

Answer 2

neuron-specific, synaptic activity dependent gene transcription

Question 3

BDNF is required for

Answer 3

enhancement of
neuronal survival
axon outgrowth
arborisation

Question 4

HDAC2 function

Answer 4

suppresses contextual fear conditioned memory formation

represses neuronal dendritic spine formation

Question 5

HDAC2 sensitive histone acetylation promotes

Answer 5

memory formation and retrieval

Question 6

Strength & persistence of memories regulated by

Answer 6

histone acetyltransferases & deacetylases.

Question 7

Histone acetylation near neuronal synaptic genes promotes

Answer 7

dendritic spine & memory formation

Question 8

Bromodomain function

Answer 8

Binds to acetylated lysine in core histones

Question 9

CBP

Answer 9

histone acetyltransferase

Question 10

PHD finger function

Answer 10

binds to methylated lysine 4 in core histone H3

Question 11

Cause of Rubinstein-Taybi syndrome

Answer 11

mutations in CBP gene

Question 12

CBP promotes

Answer 12

memory formation,
retrieval,
H2B acetylation

Question 13

TET enzyme function

Answer 13

actively & specifically remove DNA methylation patterns

Question 14

TET function in memory

Answer 14

Promote demethylation & extinction of fear conditioned memories