L13- Bone, Marrow Vessels And Blood Flashcards

1
Q

What are the types of bones?

A
  1. Long
  2. Short
  3. Flat
  4. Irregular
  5. Sesamoid
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2
Q

Outline the a) location b) structure and c) function of each bone type

A
  1. Long
    A) Appendicular skeleton- femur
    B) longer than wider
    C) to support the weight of the body and facilitate movement
  2. Short
    A) wrist (carpals) and ankle (tarsals) joints
    B) same length and width
    C) provide stability and movement
  3. Flat
    A) skull, thoracic cage and pelvis
    B) flattened with roughly parallel opposite edges
    C) protects internal organs and provides large areas of attachment for muscles
  4. Irregular
    A) vertebrae and pelvis
    B) vary in shape and structure
    C) protects internal organs, important anchor points muscle groups
  5. Sesamoid
    A) embedded in tendons of hands, knees and feet
    B) Small round bones
    C) protects tendons from stress and damage and repeated wear and tear
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3
Q

What are the two types of bone tissue?

A
  1. Cancellous/spongy bone (inner layer of all bones)

2. Compact bone/cortical bone (outer layer of all bones)

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4
Q

Compare the two types of bone marrow

A

Red marrow:

  • full of developing blood cells
  • rich blood supply
  • found in spongy bone only
  • function: replenish cells in the blood (haemopoiesis)

Yellow marrow:

  • full of adipocytes
  • poor blood supply
  • function: shock absorber and energy source
  • can convert to red marrow
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5
Q

How does bone marrow cells differ from cells in blood?

A
  • Bone marrow is where stem cells are made
  • stem cells are blood cells at the earliest stages of development (not specialised)
  • all our blood cells develop from stem cells in the bone marrow
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6
Q

Where do you find bone marrow in your body?

A

Ribs, vertebrae, sternum and bones of pelvis

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7
Q

What are the types of blood vessels in your body?

A
  1. Arteries (and arterioles)
  2. Capillaries
  3. Veins and venules
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8
Q

a) Function of arteries

b) Structure of arteries

A

a) Elastic blood vessels that carry blood AWAY from the heart
- high blood pressure: small lumen diameter and the elastin allows it to stretch but prevents over expansion
b) 3 layers: (inside to out)
1. Tunica intima: elastic membrane lining and smooth endothelium (non-fenestrated)
2. Tunica media: composed of smooth muscles and elastic fibres. this layer is thicker in arteries than in veins and has two distinct elastic layers
3. Tunica externa: strong outer covering composed of collagen and elastin

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9
Q

a) Function of capillaries
b) Types of capillaries
c) Structure of capillaries

A

a) The capillaries are responsible for facilitating the transport and exchange of gasses, fluids, and nutrients in the body.
b) Continuous, fenestrated and sinusoid
c) Smallest blood vessels. Two layers: endothelial layer surrounded by a basement membrane

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10
Q

A) What is flow through capillaries known as?

B) How is capillary flow controlled?

A

a) Microcirculation
b) By Precapillary sphincters located between arterioles and capillaries
- contain smooth muscle for contraction
- when they are open, blood flows freely to capillary beds
- when they are closed blood cannot flow to beds

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11
Q

a) Function of veins

b) Structure of veins

A

a) Elastic blood vessel that transports blood to the heart
- Low pressure system
- fibroelastic cartilaginous valves to prevent backflow
b) 3 layers: (inner to out)
1. Tunica intima; endothelial cells
2. Tunica media; elastic fibres and smooth muscles
3. Tunica externa: elastic fibrous capsule

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12
Q

What are the types of veins?

A
  1. Pulmonary veins: carry oxygenated blood from lungs to the left atrium of the heart
  2. Systemic veins: return oxygen-depleted blood from rest of the body to the right atrium of the heart
  3. Superficial veins: located close to the surface of the skin not near an artery
  4. Deep veins: located deep between tissues and are located near a corresponding artery
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13
Q

a) How do veins range in size?
b) What are the smallest veins in the body?
c) what are the largest veins in the body?

A

a) 1mm to 1-1.5cm in diameter
b) Venules
c) Superior and inferior vena cavae

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14
Q

What is the order of blood flow

A

Superior and inferior vena cava –> RA –> artery –> arterioles –> capillaries –> venules –> veins–> vena cava

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15
Q

Compare the structure and function between veins and arteries and capillaries

A
  • Arteries have much thicker walls (strength and elasticity) to deal with the higher blood pressure, prevent bursting and maintain pressure wave
  • Capillaries: Thin walls and narrow lumen to bring blood into close contact with tissues to allow diffusion of materials between capillary and tissues
  • Veins have wider lumens; to offer less resistance to blood flow
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16
Q

a) What are collateral vessels?

b) How are they developed?

A

a) - Provide protection for tissues that may become compromised
- Provide alternative path for arterial blood flow

b)
- chronic disease e.g. ischaemia or during development

17
Q

a) What is vasculogenesis?

b) what is angiogenesis

A

a) Formation of new blood vessels from angioblast precursors (bone marrow)
- occurs during embryonic development, newly formed cancers, endometriosis

b) Formation of new blood vessels from existing blood vessels e.g. during fetal development, collateral arteries and postnatal lung development

18
Q

What are the two types of angiogenesis?

A
  1. Sprouting angiogenesis: slow

2. Intussusceptive angiogenesis: splitting + quick

19
Q

What is the pericyte and what is its function?

A
  • immature smooth muscle like cell
  • found inside basal lamina
  • key component of capillaries
  • contractle properties
  • involved in nerve cell communication: BBB
  • Able to differentiate into endothelial, smooth muscle or fibroblast
  • Functions: prevents endothelial cell prolideration, maintians tight capillaries e.g. BBB
20
Q

How do cells leave the bone marrow?

A
  • Marrow sinuses are sinusoidal, discontinuous capilarries. - Mature cells enter the sinuses and are conveyed to the systemic circulation via nutrient veins.
  • On entering circulation new RBC and WBC travel from venule intermediate vein larger vein vena cava
21
Q

What is the purpose of low pressure venous systems needing muscles?

A

They aid blood flow back to heart

22
Q

Examples of long bones

A
  • major bones of upper limbs (humerus, radius and ulna)

- major bones of lower limbs (femur, tibia and fibula)

23
Q

examples of short bones

A
  • carpal bones in in wrist

- tarsal bones in the feet

24
Q

examples of flat bones

A
  • scapula, ribs, sternum and pelvic bones and bones in skull
25
Q

Examples of sesamoid bones

A
  • patella of the knee cap
26
Q

In the fetus where are the blood cells first produced?

A

Mesoderm of the yolk sac, then by liver and spleen and finaly bone marrow

27
Q

What is hematocrit?

A

the ratio of the volume of red blood cells to the total volume of blood.