L100- Tablets

Question 1

what are the 2 main solid dosage forms?

Answer 1

tablet and capsules

Question 2

what are four main methods by which tables are manufactured?

Answer 2

1. Wetgranulation
2. Drygranulation
3. Directcompression
4. Rollercompaction(Chilsonisation)

Question 3

what are the factors used to determine the choice of manufacturing process?

Answer 3

1. Compression properties of the therapeutic agent
2. Particle size of the therapeutic agent
3. Types of the excipient
4. Chemical stability of the therapeutic agent

Question 4

what are the different types of excipients?

Answer 4

• diluents/filler
• binders
• lubricant
• disintegrate
• absorbant

Question 5

what are the different types of diluents/fillers?

Answer 5

• anhydrous or mono hydrous lactose
• spray dried lactose
• starch
• Dibasic calcium phosphate
• Microcrystalline cellulose (MCC)
• Mannitol

Question 6

when is Anhydrous or mono-hydrous lactose used?

Answer 6

for both wet and dry granulation

Question 7

when is spray dried lactose used?

Answer 7

direct compression press

Question 8

what pH is Dibasic calcium phosphate?

Answer 8

it is basic

Question 9

what is Mannitol normally used in?

Answer 9

chewable tablets like lozenges

Question 10

what is a binder?

Answer 10

• mainly used in wet granulation methods.

- can be added to solutions or powders

Question 11

what is a disintegrate?

Answer 11

Added to tablet formulation to facilitate the breakdown of the tablet upon entry to stomach

Question 12

how do disintegration work? 2 ways?

Answer 12

• -increase porosity and wettablitiy- Disintegrant may increase the porosity and wettability of the compressed tablet then Gastrointestinal fluids penetrate to the bulk of the tablet and break it up
• -May occur by swelling in the presence of aqueous fluids, thus increasing the internal pressure within the tablet

Question 13

what are he different types of lubricants?

Answer 13

• insoluble

- soluble

Question 14

when would you use a soluble lubricant?

Answer 14

They are employed when the insoluble counter parts affect on disintegration

Question 15

what is a glidant?

Answer 15

Enhances the flow properties of the powders within the hopper into the tablet press

Question 16

what is an adsorbents?

Answer 16

These materials are used whenever required to include a liquid or semisolid components.

Question 17

what is a sweetening agent?

Answer 17

added to control the taste, and very important in with bitter drugs and chewable tablet

Question 18

what is a colouring agent?

Answer 18

added to improve the appearance of the tablet or to IDENTIFY the finished product

Question 19

what is a surface-active agent?

Answer 19

added to enhance the wettability of hydrophobic tablets and aids the rate of disintegration.

Question 20

what needs to be done to manufacture tablets by wet granulation?

Answer 20

1. Mixing of the therapeutic agents with the powdered excipients (excluding lubricant) into the powder mixer
2. Homogeneous mixing is essential throughout the mixture
3. The mixing is better if the average particle sizes are similar

Question 21

what are the different types of industrial mixers?

Answer 21

• Rotating drug mixer

- high speed mixer