L1 Principles of Pharm Flashcards
Generic name of (+/-)-2-(p-isobutylphenyl) propionic acid
ibuprofen
Trade name of (+/-)-2-(p-isobutylphenyl) propionic acid
Motrin
What is Pharmacognosy
Study of the plant or animal that the drug comes from
What is Pharmokinetics
Effect of the body on the drug
ADME- Absorption, Distribution, Metabolism, Excretion
What is Pharmodynamics
Effect of the drug on the body
-onset of action
-duration of drug in the body
What is Pharmodynamics
Effect of the drug on the body
-onset of action
-duration of drug in the body
What is Pharmacotherapeutics
The use of drugs and the clinical indications for
drugs to prevent and treat diseases
what is the plant source of cocaine
coca leaves
what is the plant source of Sudafed
Ephedra
what is the plant source of digoxin
digitalis
what is the source of opioid drugs
opium poppy seed
What is Toxicology
potential harmful effects of drugs usually when administered in higher doses
what is the function of Glipizide
-oral hypoglycemic
-lower blood sugar
-diagnostic for Diabetes mettitus
what 2 drugs are used for diagnosis and treatment of pheochromocytoma
Phentolamine and phenoxybenzamine
- they do so by inhibiting NE from binding, therefore blood sugar is not lowered
what is hydrochlorothiazide used to treat
-used to treat edema
- its a diuretics
what is the function of digitalis (digoxin)
increases force and rate of contraction of heart to treat heart failure
what substances are considered PURE PLACEBO
-lactose capsules
-sodium chloride injection
what is IMPURE placebo
a drug that has another effect but not the intended effect.
-ex: ASA (acetylsalicylic acid)/ aspirin, B12, vit C
what is required for a drug to pass through a membrane
-lipid soluble
-non- ionized
-neural
-pronated
What happens during absorption
drug travels through a barrier(cell membrane) to enter the systemic circulation
what is an active metabolite
change of the drug that still have clinical effect after the drug was metabolized
ways in which a drug can pass a membrane
-diffuse through barrier
-diffuse through aqueous channel
-bind to carrier protein
Describe a weak acid at acid pH
-lipid-soluble, because it is uncharged–the uncharged form more readily passes through biological membranes.
-Note that a weak acid at acid pH will pick up a proton a become uncharged.
RCOO- + H+ ⇄ RCOOH
Describe a weak base at base pH
-more lipid-soluble, because it is uncharged–the uncharged form more readily passes through biological membranes.
-Note that a weak base at more alkaline pH will lose a proton, becoming uncharged.
RNH3+ ⇄ RNH2 + H+