L1- Introduction to influenza virus and its transcription and replication

Question 1

What is the structure of Influenza A?

Answer 1

Slide 3-4

Question 2

What is the life cycle of Influenza A?

Answer 2

Slide 5-6

Question 3

What is the structure of its RNA polymerase? How does it mediate RNA transcription?

Answer 3

Slide 7-11

Question 4

Give the model of our current understanding of RNA transcription.

Answer 4

Slide 12

Question 5

What are ANP32 proteins? What do they do?

Answer 5

Slide 13-17

Question 6

What is the current model of viral genome replication?

Answer 6

Slide 18

Question 7

How does ANP32A differ between species and what effect does this have

Answer 7

Slides 19-22

Question 8

What strategies do negative and positive sense RNA viruses use to hide their RNA genomes from innate immune sensing?

Answer 8

Slide 24-25

Question 9

What strategies do negative and positive sense RNA viruses use to hide their RNA genomes from innate immune sensing?

Answer 9

Slides 24-25

Question 10

How is Influenza A detected by the immune system and how does it stimulate the immune system?

Answer 10

Slides 26-30

Question 11

What two roles does Influenza’s RNA polymerase perform? How does it have multiple functions?

Answer 11

Slides 31-32

Question 12

How can its RNA polymerase be targetted and how can more target sites in the RNA polymerase be identified?

Answer 12

Slides 33-34