L1 - Introduction to Developmental Biology Flashcards
What are the implications of development not stopping at birth?
The UK population is ageing faster than its growth
How much of the UK welfare budget is spent on pensioners?
55%
What are the 3 experimental approaches to developmental biology?
Animal models
Microscopy
Genetics
What is the epigenesis theory?
Organisms develop progressively through the generation of new structure and forms
Who came up with the epigenesis theory?
Aristotle
345 BC
What is the preformationism theory?
Organisms develop from miniature versions of themselves - homunculus
Who came up with the preformationism theory?
Nicolaas Hartospeker
1695
What is cell theory?
All organisms are composed of one or more cells
The cell is the most basic unit of structure, function, and organization
All cells arise from pre-existing, living cells
What led to discovery of the cell?
Microscope technology
Robert Cooke
1665
How cells become different from each other - germ plasm determinants theory
Cells may show a subset of the programme available – somatic cells
Cells may show the whole programme – germ cells
Who came up with the germ plasm determinants theory?
Friedrich Leopold August Weismann
1880
Experimental demonstration of Weismanns theory method
- Took fertilised frog egg and allowed it to develop to 2 cell stage
- Burned half
- Only half developed with cell fate – disrupted cell-cell signalling
Wilhem Roux
1888
How cells become different from each other - induction theory
- Took sea urchin egg and allowed it to develop to 2/4 cell stage
- Separated the cells from each other and allowed them to develop
- Each of the cells lead to the development of a full embryo
Who came up with the induction theory?
Hans Driesch
What are the two ways cells communicate with each other via cues?
Intrinsic cues – cell differentiates into another
Extrinsic cues – cell influences/instructs another cell