L 39 Uterine Drugs

Question 1

Oxytocin

Answer 1

DOC for labor induction of term pregnancies
2nd line treatment for hemorrhage–injected
Used for milk let down

Adverse: water intoxication, uterine rupture, anaphylaxis, sinus bradycardia of fetus

Question 2

Ergonovine maleate (Ergotrate)
Methylergonovine maleate (Methergine)

Answer 2

Ergot Alkaloids
Bind serotonin and alpha adrenergic receptors to cause uterine contraction and smooth muscle contraction
Used after delivery of everything including the placenta to cause intense contraction to stop hemorrhage after massage and oxytocin have failed
Rapid action, lasts hours
Never use for labor or with vascular problems or CAD

Question 3

Dinoprostone (Prostin E2)

Answer 3

Synthetic PGE2
Used for expulsion of uterine contents and cervical ripening before delivery
DIARRHEA

Question 4

Carboprost tromethamine

Answer 4

PGF2alpha derivative

Induce abortion or used 3rd line for post partum bleeding

Question 5

Magnesium Sulfate (MgSO4)

Answer 5

First line drug to relax uterus and prevent delivery
Can treat preeclampsia convulsion
IV only so must be in hospital

Question 6

Nifedipine (Procardia)

Answer 6

L-type Ca channel blocker to prevent smooth muscle contraction
Used to prevent preterm labor

Question 7

Indomethacin (Indocin)

Answer 7

Blocks PG synthesis to prevent preterm labor and relax uterus
Can close the ductus arteriosus in fetus

Question 8

Progesterone use in preterm labor

Answer 8

Used as prophylaxis only, not acute treatment to prevent labor

Question 9

Nitroglycerin

Answer 9

Used as emergency drug to relax uterus when ruptures

Fast onset, lasts 1 minute