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Pharm Final NEW > L 36 Anti Infectives > Flashcards

L 36 Anti Infectives Flashcards

1
Q

What drugs are Cell Wall Inhibitors? (B lactams)

A

Penicillins

Cephalosporins

Ampicillin

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2
Q

B Lactam MOA?

A

Attach to penicillin binding proteins
= (-) cross links in cell wall

= lysis and death bactericidal

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3
Q

Penicillins & Cephalosporins SE?

A

toxic rxn = massive dose

greatest risk = anaphylactic shock

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4
Q

4 Mechanisms of B Lactam Resistance?

A
  1. Inactivation of B lactic ring
  2. Alterations of PBP
  3. Reduction of antibiotic access to PBPs
  4. Elaboration of efflux mechanisms
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5
Q

What drugs are Cell Metabolism Inhibitors?

A

Macrolides
Tetracyclines
Aminoglycosides

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6
Q

Macrosides MOA?

A

(-) 50S

bacterioSTATIC

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7
Q

Tetracyclines MOA?

A

(-) 30S

bacterioSTATIC

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8
Q

Aminoglycosides MOA?

A

(-) 30S

bacterioCIDIAL

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9
Q

Tetracycline SE?

A

make teeth brown

anything w/ a metal cation reduces absorption

so pt cant have dairy

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10
Q

Aminoglycosides SE?

A

Ototoxicity

Nephrotoxicity

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11
Q

What drugs are Folic Acid inhibitors?

A

Sulfonamides

Trimethoprim

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12
Q

Sulfonamides SE?

A

crystal formation – kidney obstruction

toxic encephalopathy in newborn

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13
Q

Trimethoprim SE?

A

use in pregnancy will affect fetus

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14
Q

What drugs (-) Replication?

A

quinolones

floroquinolones

nitrofuran

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15
Q

Quinolones MOA?

A

(-) DNA synthesis

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16
Q

Fluoroquinolones MOA?

A

bacteriostatic but become cidial

17
Q

Nitrofurans MOA?

A

static & cidial

18
Q

Amphotericin B MOA?

A

binds ergosterol
= disrupt membrane

fung ICIDAL

19
Q

Amphotericin B SE?

A

nephrotoxicity

20
Q

What drugs (-) ergestrol synthesis?

A

Azoles

Allylamines

21
Q

Azole MOA?

A

(-) Iaosterol demethylase
(-) ergestrol synthesis

fungi STATIC

22
Q

Azole SE?

A

cant give w/

H2 antagonists 
Proton Pump (-)

Antacids
Vitamin supplements

23
Q

Allylamines MOA?

A

fungi CIDIAL

24
Q

Echinocandin MOA?

A

(-) glucan

(-) cell wall synthesis

fungiCIDIAL

25
Q

Echinocandins Tx?

A

IV

Candida, Aspergillus spp

Oropharyngeal/ esophageal candidasis

Pharm Final NEW (3 decks)

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