L 34 Anti Histamines

Question 1

What is the 1st Generation H1 antihistamines MOA?

Answer 1

competitive antagonist of H1

anti cholinergic = Anti SLUDE

Question 2

1st Generations cross?

Answer 2

BBB

Placenta

Question 3

1st Generation uses?

Answer 3

allergy
sedation/ sleep aid

motion sick, nausea
cough suppressant

Question 4

What drugs are 1st Generation H1 Antagonists?

Answer 4

Diphenhydramine
Hydroxyzine
Chlorpheniramine

Cyclizine
Dimenhydrinate

Meclizine
Promethazine

Question 5

1st Generation SE?

Answer 5

Sedation

Tachycardia

Question 6

2nd Generation uses?

Answer 6

non sedating anti allergy

Question 7

2nd Generation Drugs?

Answer 7

Fexofenadine
Loratadine

Cetirizine
Desloratadine

Question 8

Cetirizine SE?

Answer 8

higher sedative effect

pilots cant use it

Question 9

H2 receptor antagonists MOA?

Answer 9

reduce stomach acid production by parietal cells

Question 10

H2 antagonists Drugs?

Answer 10

• idine

Cimetidine
Famotidine
Ranitidine

Question 11

Undesirable runs produced by the immune system to an otherwise innocuous antigen

Answer 11

Hypersensitivity

Question 12

What does hypersensitivity lead to?

Answer 12

Vascular Perm
Vasodilate
SM Contraction
Local Infl

Question 13

Type 1 Hypersensitivity?

Answer 13

IgE

seasonal allergies
food allergies
hives
eczema

Question 14

Type 2 Hypersensitivity?

Answer 14

IgG

transfusion rxn

Question 15

Mast Cell Stabilizers MOA?

Answer 15

Prevent release of Histamine from mast cells

Question 16

Mast Cell Stabilizers uses?

Answer 16

allergic rhinitis
conjunctivitis
asthma

Question 17

Mast Cell Stabilizer Drugs?

Answer 17

Cromolyn Na+
Nedocromik

(Nasal Crom!)

Question 18

Mast Cell Stabilizers SE?

Answer 18

cough

bitter tastse – no pt compliance