Kruse Pharm Flashcards
What drug can be used to treat kids with short stature? What would inhibit it?
Somatropin (GH)
Somatostatin would inhibit it
What receptor signaling pathway does GH act on?
RTK pathway
What is the MOA and clinical use of Octreotide/Lanreotide?
SST analogs- GH antagonist
Used for inhibiting GH release in pituitary adenomas
What drug blocks the GH receptor?
Pegvisomont
What would Mecasermin be used for?
IGH-1 deficiency not responsive to exogenous GH
What is the treatment for hyperprolactinemia?
Dopamine receptor agonists: Bromocriptine and cabergoline–> blocks prolactin release
What agents block iodide organification, used for hyperthyroidism?
Propylthiouracil and Methimazole
What is the major adverse effect of Propylthiouracil?
Agranulocytosis and hepatitis
What hormones act through kinase receptors?
Insulin–> RTK (MAP)
TGF-B–> Serine/threonine kinase
GH and PRL–> Cytokine receptor (JAK/STAT)
What is the signaling cascade of Gs GPCRs?
Hormone binds to GPCR–> adenylyl cyclase–> cAMP–> PKA phosphorylates proteins
What is the signaling cascade of Gq GPCRs?
Hormone binds–> activates Phospholipase C (PLC)–> converts PIP2 to DAG and IP3. DAG activates PKC and IP3 causes Ca++ release from ER
What hormones act through the adenylyl cyclase pathway?
FLAT ChAMP
FSH, LH, ACTH, TSH, CRH, hCG, ADH (V2), MSH, PTH
plus glucagon
What hormones act through the IP3 pathway?
GOAT
GnRH, Oxytocin, ADH (V1), TRH
What hormone acts through a Gi pathway on a-adrenergic receptors?
Somatostatin (inhibitory)
What receptors should be antagonized in the tx of SIADH? What drugs do this?
Vasopressin receptors (V1 and V2) Tolvapatan (V2) and Conivaptan (V1, V2)
