KRUSE Effects of anti-hypertensive agents on components of the RAS

Question 1

Direct renin inhibitors on PRC, PRA, ANG I, ANG II, ACE, Bradykinin, AT1, AT2

Answer 1

1. PRC: increases ( i think plasma renin contraction means the extent to which it diminishes)
2. PRA: decrease
3. Ang I: decreases
4. Ang II: decreases
5. ACE: the same
6. AT1: the same
7. AT2: the same

Question 2

ACEI on PRC, PRA, ANG I, ANG II, ACE, Bradykinin, AT1, AT2

Answer 2

1. PRC: increases
2. PRA: increases
3. Ang I: increases
4. Ang II: decreases
5. ACE: decreases
6. Bradykinin: increases
7. AT1: neutral
8. AT2: neutral

Question 3

ARBs on PRC, PRA, ANG I, ANG II, ACE, Bradykinin, AT1, AT2

Answer 3

1. PRC: increases
2. PRA: increases
3. ANG I: increases
   4: ANG II: increases
4. ACE: neutral
5. Bradykinin: neutral
6. AT1: inhibited

AT2: stimulated

Question 4

Diuretics on PRC, PRA, ANG I, ANG II, ACE, Bradykinin, AT1, AT2

Answer 4

1. PRC: increases
   2: PRA: increases
2. Ang I: increases
3. Ang II: increases

Question 5

Ca2+ channel blocker on PRC, PRA, ANG I, ANG II

Answer 5

all neutral

Question 6

beta blockers on PRC, PRA, ANG I, ANG II

Answer 6

all listed are neutral