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IMMS > krebs cycle > Flashcards

krebs cycle Flashcards

1
Q

Where does the Krebs cycle take place?

A

Matrix of mitochondria

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2
Q

Which enzyme catalyses conversion of citrate to isocitrate?

A

Aconitase

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3
Q

What is the function of aconitase?

A

Catalyses conversion of citrate to isocitrate

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4
Q

Which enzyme catalyses conversion of isocitrate to a-Ketoglutarate?

A

Isocitrate dehydrogenase

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5
Q

What is the function of isocitrate dehydrogenase?

A

Catalyses conversion of isocitrate to a- ketoglutarate, forming NADH and CO2

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6
Q

Which enzyme catalyses conversion of a-Ketoglutarate to succinyl-coA?

A

a-Ketoglutarate dehydrogenase complex

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7
Q

What is the function of a-ketoglutarate dehydrogenase complex?

A

Catalyses conversion of a-ketoglutarate to succinyl-coA, forming NADH and CO2

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8
Q

Which enzyme catalyses conversion of succinyl-coA to succinate?

A

Succinyl co-A synthetase

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9
Q

What is the function of succinyl-coA synthetase?

A

Conversion of succinyl-coA to succinate, releasing GTP

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10
Q

Which enzyme catalyses conversion of succinate to fumarate?

A

succinate dehydrogenase

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11
Q

What does succinate dehydrogenase catalyse?

A

Conversion of succinate to fumarate, releasing 2H- to form FADH2

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12
Q

Which enzyme catalyses conversion of fumarate to malate?

A

Fumarase

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13
Q

What is the function of fumarase?

A

Conversion of fumarate to malate

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14
Q

Which enzyme catalyses conversion of malate to oxaloacetate?

A

malate dehydrogenase

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15
Q

What does malate dehydrogenase catalyse?

A

conversion of malate to oxaloactetate, forming NADH

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16
Q

What is the first step of the Krebs cycle?

A

Pyruvate converted to acetyl co-A by pyruvate dehydrogenase complex, releasing NADH and CO2

17
Q

Which enzyme catalyses conversion of pyruvate to acetyl coA?

A

pyruvate dehydrogenase complex

18
Q

Give 3 sources of acetyl co-A

A

from pyruvate,

beta oxidation of fatty acids, or breakdown of amino acids

19
Q

Why does the TCA cycle only occur aerobically?

A

oxidative phosphorylation is required to convert NADH and FADH2 back to NAD+/FAD+ co-enzymes

20
Q

Where does pyruvate come from?

A

Glycolysis

21
Q

What is pyruvate converted into?

A

acetyl coA

22
Q

What is acetyl coA converted into?

A

Citrate

23
Q

What is citrate converted into?

A

Cis-aconitate

24
Q

What is cis-aconitate converted into?

A

Isocitrate

25
Q

What is isocitrate converted into?

A

a-ketoglutarate

26
Q

What is a-ketoglutarate converted into?

A

Succinyl coA

27
Q

What is succinyl coA converted into?

A

Succinate

28
Q

What is succinate converted into?

A

Fumarate

29
Q

What is fumarate converted into?

A

Malate

30
Q

What is malate converted into?

A

Oxaloacetate

31
Q

What does oxaloacetate combine with, and what does this form?

A

Acetyl coA, forming citrate

IMMS (2 decks)

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