Kreb's Cycle

Question 1

What is the function of the Kreb’s cycle and where does it occur

Answer 1

-oxidize acetyl-CoA to CO2
-generating NADH, FADH2, GTP/ATP

-mitochondrial matrix

Question 2

Why is TCA cycle critical for cellular respiration

Answer 2

it produces high-energy electron carriers (NADH and FADH2) that fuel ETC —> ATP synthesis

Question 3

What are the substrates and products of one turn of the TCA cycle

Answer 3

Inputs:
Acetyl-CoA
3 NAD+
FAD
ADP (GDP)
Pi

Outputs:
2 CO2
3 NADH
1 FADH2
1 ATP (GTP)
CoA-SH

Question 4

What are the 8 steps of Kreb’s Cycle

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Answer 4

1. Citric acid
2. Isocitrate
3. Alpha Ketogluterate
4. Succinyl CoA
5. Succniate
6. Fumerate
7. Malate
8. Oxaloacetate

Question 5

What enzymes are associated with the 8 Steps of the Kreb’s Cycle

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Answer 5

1. Citrate synthase
2. Aconitase
3. Isocitrate Dehydrogenase
   - NADH and CO2 produced
4. alpha-Ketogluterate Dehydrogenase
   -NADH and CO2 produced
5. Succinyl-CoA Synthetase
   -ATP generated
6. Succinate Dehydrogenase
   -FADH2 produced
7. Fumarase
8. Malate Dehydrogenase
   -NADH produced

Question 6

What does Dehydrogenase refer to

Answer 6

-facilitate the oxidation (loss of electrons) of their substrate by removing hydrogen atoms

-type of enzyme that catalyzes the removal of hydrogen atoms

-then transfers the hydrogen atom to an electron carrier (NAD+, FAD, NADP+)

-this transfer leads to reduction
NAD+ —> NADH
FAD —>FADH
NADP+ —> NADPH