Krafts- Acute lymphoblastic anemia

Question 1

What is ALL?

Answer 1

Malignant proliferation of lymphoid blasts in blood and bone marrow

Question 2

How do you classify ALL?

Answer 2

immunophenotype (B vs. T)

Question 3

ALL is most common in….and the prognosis often is….

Answer 3

CHILDREN

GOOD

Question 4

TLL is most common in ______ with _____mass. WBC is usually______.

Answer 4

Males
Mediastinal mass
Elevated WBC

Question 5

What is the prognosis for the young man w/ a mediastinal mass and t- lymphoblastic lymphoma?

Answer 5

Usually bad….worse for B than T.

Question 6

True or false

B lymphoblastic leukemia often is positive for TdT and rarely positive for the philadelphia chromosome.

Answer 6

True

Question 7

How do you determine the prognosis in ALL?

Answer 7

The prognosis depends on

Immunophenotype (T is bad)

Age (1-10) good

WBC (<10,000) good

Cytogenetics (hyperdiploidy good)

Question 8

How do you treat ALL?

Answer 8

chemo +/- bone marrow transplant

Many children are cured!