KISS Flashcards
which order is bad?
zero
what does first order kinetics mean?
constant FRACTION is eliminated per time
What does 0th order kinetics mea?
constant AMOUNT is eliminated per time
which kind of inhibition changes the Km? why?
Km increases with competitive inhibition because the affinity and potency for substrate decreases. because the guy looks just like you
Km is indication of what
affinity to substrate. higher Km=lower affinity
noncompetitive inhbitor binds where?
regulatory site binding
non competitive irreversible inhibitor influences what?
Vmax. that’s your boss who makes you unable to work no matter how you try
Km is same as what
potency
Vmax is same as what
effecacy
therapeutic index equation
median lethal dose/median effective
what is better..low or high therapeutic index?
low is good
therapeutic window is window is what?
effective and safe
what’s the definition of Km?
the amount of substrate at 1/2 of V max
how much drug is elimiated at 3 T1/2
87.5%
how much drug is eliminated at 4 T1/2
94%
decreases mortality in subarachnoid hemorrh
Nimodipine
decreases risk of esphageal bleed in liver failure
nadolol
Adenosine is blocked by what?
Theophylline and caffeine
Digoxin toxicty treatment?
Magnesium
blurred yellow vision
Digoxin
blue vision changes
sildenafil
Blue/green visual changes
Ethanbutol
Digoxin toxicty treatment?
Magnesium, digoxin immuno fab
What must you monitor when on digoxin? what’s the importance
potassium; hyperkalemia is a bad prognosis
why use digoxin in afib?
decrease AV conduction (and SA)
Why use digoxin in CHF
potentiates myocyte contractility
ECG findings of digoxin?
increased PR decreased QT (risk for AV block)
ST scooping/inversion
what drugs decreases clearance of digoxin?
verapamil, quinidine, and Amiodarone
what factors predispose people to digoxin toxicity?
Hypokalemia (DIURETICS!), renal failure, drugs that inhibit digoxin (verapamil, amiodarone, and quinidine)
