KISS

Question 1

which order is bad?

Answer 1

zero

Question 2

what does first order kinetics mean?

Answer 2

constant FRACTION is eliminated per time

Question 3

What does 0th order kinetics mea?

Answer 3

constant AMOUNT is eliminated per time

Question 4

which kind of inhibition changes the Km? why?

Answer 4

Km increases with competitive inhibition because the affinity and potency for substrate decreases. because the guy looks just like you

Question 5

Km is indication of what

Answer 5

affinity to substrate. higher Km=lower affinity

Question 6

noncompetitive inhbitor binds where?

Answer 6

regulatory site binding

Question 7

non competitive irreversible inhibitor influences what?

Answer 7

Vmax. that’s your boss who makes you unable to work no matter how you try

Question 8

Km is same as what

Answer 8

potency

Question 9

Vmax is same as what

Answer 9

effecacy

Question 10

therapeutic index equation

Answer 10

median lethal dose/median effective

Question 11

what is better..low or high therapeutic index?

Answer 11

low is good

Question 12

therapeutic window is window is what?

Answer 12

effective and safe

Question 13

what’s the definition of Km?

Answer 13

the amount of substrate at 1/2 of V max

Question 14

how much drug is elimiated at 3 T1/2

Answer 14

87.5%

Question 15

how much drug is eliminated at 4 T1/2

Answer 15

94%

Question 16

decreases mortality in subarachnoid hemorrh

Answer 16

Nimodipine

Question 17

decreases risk of esphageal bleed in liver failure

Answer 17

nadolol

Question 18

Adenosine is blocked by what?

Answer 18

Theophylline and caffeine

Question 19

Digoxin toxicty treatment?

Answer 19

Magnesium

Question 20

blurred yellow vision

Answer 20

Digoxin

Question 21

blue vision changes

Answer 21

sildenafil

Question 22

Blue/green visual changes

Answer 22

Ethanbutol

Question 23

Digoxin toxicty treatment?

Answer 23

Magnesium, digoxin immuno fab

Question 24

What must you monitor when on digoxin? what’s the importance

Answer 24

potassium; hyperkalemia is a bad prognosis

Question 25

why use digoxin in afib?

Answer 25

decrease AV conduction (and SA)

Question 26

Why use digoxin in CHF

Answer 26

potentiates myocyte contractility

Question 27

ECG findings of digoxin?

Answer 27

increased PR decreased QT (risk for AV block)

ST scooping/inversion

Question 28

what drugs decreases clearance of digoxin?

Answer 28

verapamil, quinidine, and Amiodarone

Question 29

what factors predispose people to digoxin toxicity?

Answer 29

Hypokalemia (DIURETICS!), renal failure, drugs that inhibit digoxin (verapamil, amiodarone, and quinidine)