kidneys (extra slides) quiz 1 Flashcards
Chronic kidney disease definition
-Involves progressive, irreversible loss of kidney function
Defined as presence of:
Kidney damage
- Pathological abnormalities
- Markers of damage
- Blood, urine, imaging tests
-Glomerular filtration rate (GFR) <60 mL/minute/1.73m2 for 3 months or longer (normal 125ml/min)
clinical manifestation of chronic kidney disease
Result of retained substances
- Urea
- Creatinine
- Phenols
- Hormones
- Electrolytes
- Water
- Other substances
- Uremia (Syndrome that incorporates all signs and symptoms seen in various systems throughout the body )
clinical manifestations of chronic kidney disease: urinary system
Polyuria
- results from inability of - - kidneys to concentrate urine.
- occurs most often at night (nocturia).
- specific gravity fixed around 1.010.
Oliguria (low urine output)
- occurs as CKD worsens.
Anuria
- Urine output <40 mL per 24 hours
clinical manifestations of CKD: metabolic disturbances
Waste product accumulation
- As GFR decreases, BUN increases and serum creatinine levels increases
BUN increases
- not only by kidney failure but by protein intake, fever, corticosteroids, and catabolism.
- N/V, lethargy, fatigue, impaired thought processes, and headache may occur.
Altered carbohydrate metabolism
- Caused by impaired
glucose use
- From cellular insensitivity to the normal action of insulin
Defective carbohydrate metabolism
- Clients with diabetes who become uremic may require less insulin than before onset of CKD.
- Insulin dependent on kidneys for excretion
Elevated triglycerides
- Hyperinsulinemia stimulates hepatic production of triglycerides.
- Altered lipid metabolism
- Decrease levels of enzyme lipoprotein lipase
-Important in breakdown of lipoproteins
clinical manifestations CKD: elctrolye/ acid-base imbalances
Hyperkalemia
- Most serious electrolyte disorder in kidney disease
- Fatal dysrhythmias
Sodium
- May be normal or low
-Because of impaired excretion, sodium is retained.
Water is retained.
causes: Edema, Hypertension, CHF
Calcium and phosphate alterations
Magnesium alterations
Metabolic acidosis
Results from:
- Inability of kidneys to excrete acid load (primary ammonia)
- Defective reabsorption/regeneration of bicarbonate
clinical manifestations CKD: Hematological system
Anemia
- Due to decreased production of erythropoietin
(From decrease in functioning renal tubular cells)
Bleeding tendencies
- Defect in platelet function
Infection
- Changes in leukocyte function
- Altered immune response and function
- Diminished inflammatory response
clinical manifestation CKD: cardiovascular system
Hypertension
Heart failure
Left ventricular hypertrophy
Peripheral edema
Dysrhythmias
Uremic pericarditis
clinical manifestation CKD: resp system
Kussmaul’s respirations
Dyspnea
Pulmonary edema
Uremic pleuritis
Uremic pneumonitis (uremic lung)
Pleural effusion
Predisposition to respiratory infection
clinicla manifestations CKD: GI system
Every part of GI is affected due to excessive urea
- Stomatitis with exudates and ulcerations
- Uremic fetor (urinous odour of breath)
- GI bleeding
clinical manfestations CKD: neuro
Expected as renal failure progresses
Attributed to
- Increased nitrogenous waste products
- Electrolyte imbalance
-Metabolic acidosis
- Axonal atrophy
- Demyelination of nerve fibres
Restless legs syndrome
Muscle twitching
Fatigue, irritability
Apathy
Decreased ability to concentrate
Peripheral neuropathy
clinical manifestatioins CKD: musco-skeletal system
CKD mineral and bone disorder
- Systemic disorder of mineral and bone metabolism
- Results in skeletal complications (renal osteodystrophy) and extraskeletal (vascular and soft tissue complications) calcifications
clinical manifestations CKD: Integumentary system
Pruritus
Uremic frost
Clinical manifestations CKD: reproductive system
Infertility
- Experienced by both sexes
Decreased libido
Low sperm counts
Sexual dysfunction
clinical manifestations CKD: psycological
Personality and behavioural changes
Emotional lability
Withdrawal
Depression
how to diagnos CKD
History and physical examination
Dipstick evaluation
Albumin–creatinine ratio (first morning void)
GFR\Renal ultrasound
Renal scan
CT scan
Renal biopsy