Kidneys Flashcards
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Renal corpuscle
Top = parietal epithelium, bowman’s space, podocyte (visceral epi) and capillary
Middle = mesangial cells in mesanglial matrix
Bottom = endothelial cells
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top = parietal epithelium then bowman’s space
next cells - podocytes (visceral epithelium) and capillary
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mesangial cell in mesangial matrix
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top line = endothelial cell
bottom line = capillary
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podocytes on surface of glomellular capillaries
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glomerulus with interconnected capillaries on top
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podocyte cell body showing primary and secondary foot processes
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Podocytes
white is bowman’s space
Glomeullar capillaries
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1= bowman’s space
2 = fenestrated cap
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filtration barrier
comprised of
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mesangial cells and mesangial matrix
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mesangial cells and mesangial matrix plastic embedded
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1 = proximal convoluted
2 = distal convoluted
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more red = PCT
less red = DCT
think about why it is staining red with acid phosphatase!! lysosomes!!!
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endocytic vessicles
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proximal convoluted tubule
THINK: microvilli, endocytic vessicles, lysosomes, mitochondria, lateral PM interdigitation, basal PM infoldings
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infoldings of basal plasma membranes containing mitochondia = typical of ion transport membranes
*contain NA KTPase pump
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typical ion transporting scheme
lateral PM interdigitation with indistinct cell borders
Basal PM infldings contain mitochondria with sodium pumps
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distal convoluted tubule
NOTE: no brush border, sparse microvilli, nucleus at upper portion of cell, basal plasma membrane infoldings, mitochondria
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limbs of loop of henle and vasa recta
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loop of henle
NOTE: simple squamous epithelial cells, no brush borders, few organelles, no basolateral interdigitation
*arrow = nearby vasa recta
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collecting ducts
NOTE: pale staining cells that go cuboidal to columnar, lack brush border and have distinct cell border
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macula densa
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L arrow = macula densa
R arrow = extra golmerular mesangial cells
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arrows pointing to JG cells containing granules
*secreted into circulation in response to decreased sodium concentration in tubular fluid (promoted by signaling from macula densa)
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outer wall of bladder has three layers of smooth muscle