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AP numbers :) > Kidney numbers pt 2 > Flashcards

Kidney numbers pt 2 Flashcards

1
Q

Plasma oncotic pressure in middle of glomerular capillaries:

A

32 mmHg

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1
Q

Plasma oncotic pressure in afferent arteriole:

A

28 mmHg

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2
Q

Plasma oncotic pressure in beginning of glomerular capillaries:

A

28 mmHg

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3
Q

Plasma oncotic pressure at the end of glomerular capillaries:

A

36 mmHg

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4
Q

Hydrostatic pressure of the tubule:

A

18 mmHg

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5
Q

Protein osmotic pressure in the early part of the tubule:

A

0 mmHg

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6
Q

Net filtration pressure of kidney:

A

10 mmHg

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7
Q

Filtration rate of kidney:

A

125 mL/min

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8
Q

KF (filtration coefficient) in kidney:

A

12.5 mL/min/mmHg

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9
Q

How to solve for filtration coefficient?

A

Filtration rate / NFP

In kidney:
125 mL/min (filtration rate) divided by 10 mmHg (NFP) = 12.5 mL / min / mmHg

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10
Q

How did we get NFP of the kidney?

A

Take the pressure that promotes filtration - pressures that oppose filtration

60 mmHg (BP in glomerular capillaries) - 32 mmHg (osmotic pressure of glomerular capillaries) - 18 mmHg (Hydrostatic pressure of the tubule) = 10 mmHg

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11
Q

Filtration rate equation

A

Filtration rate = NFP x KF

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12
Q

Relaxation of the efferent arteriole = ____ upstream pressure, ___ filtration

A

reduced, less

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13
Q

Constriction of the efferent arteriole = ___ upstream pressure, ___ filtration

A

higher, more

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14
Q

BP at the end of the efferent arteriole

A

18 mmHg

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15
Q

Difference in bp between the glomerular capillaries and end of efferent arteriole

A

42 mmHg decrease

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16
Q

What % of stuff that is filtered is reabsorbed?

A

99%

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17
Q

What % of stuff that is filtered is excreted?

A

1-2%

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18
Q

Renal artery blood pressure

A

100 mmHg

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19
Q

Blood pressure of glomerular capillaries

A

60 mmHg (2x systemic caps)

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20
Q

Normal GFR

A

125 mL/min

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21
Q

Afferent arteriole plasma oncotic pressure

A

28 mmHg

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22
Q

Oncotic pressure in the beginning of the glomerular capillaries

A

28 mmHg

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23
Q

Oncotic pressure in the end of the glomerular capillaries

A

36 mmHg

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24
Q

Oncotic pressure in the middle of the glomerular capillaries

A

32 mmHg

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25
Q

Hydrostatic pressure in tubule or bowman’s capsule

A

18 mmHg

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26
Q

Oncotic pressure of tubule or bowman’s capsule

A

0 mmHg

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27
Q

NFP of glomerular capillaries

A

10 mmHg

28
Q

Filtration coefficient of glomerular capillaries

A

12.5 ml/min/mmHg

29
Q

BP at end of efferent arteriole

A

18 mmHg

30
Q

Change in pressure from glomerular capillaries to end of efferent arteriole

A

42 mmHg

60-18 = 42

31
Q

Change in pressure from renal artery to glomerular capillaries

A

40 mmHg

100-60=40

32
Q

Peritubular capillaries plasma oncotic pressure

A

32 mmHg

33
Q

Blood pressure of peritubular capillaries

A

13 mmHg

34
Q

Renal interstitial oncotic pressure

A

15 mmHg

35
Q

Renal interstitial physical fluid pressure or hydrostatic pressure

A

6 mmHg

36
Q

Peritubular capillaries NFP

A

-10 mmHg

37
Q

Peritubular capillaries net reabsorption pressure

A

+10 mmHg

38
Q

Filtration rate equation

A

Filtration rate = NFP x Filtration coefficient

39
Q

A little over ___% of the blood that moves through the kidney is filtered

A

10%

40
Q

___ of the plasma that moves through the kidneys gets filtered

A

1/5

41
Q

Filtration fraction of kidneys %?

A

20%

GFR (125) divided by renal plasma flow (660 mL/min)

42
Q

Renal plasma flow in ml/min

A

660 ml/min

43
Q

Renal blood flow in ml/min

A

1100 ml/min

44
Q

Normal HCT

A

0.40

45
Q

How do we get our plasma flow or volume for the kidneys?

A

Take 0.60 x 1100 (RBF) = 660

46
Q

Kidneys will autoregulate between these blood pressures:

A

50-150 mmHg

47
Q

Normal urine output

A

1 ml/min

48
Q

How many nephrons are in each kidney at birth?

A

1 million

49
Q

How many nephrons do we have at birth?

A

2 million (1 mil each kidney)

50
Q

This percentage of nephrons are cortical nephrons

A

90-95%

51
Q

This percentage of nephrons are deep medullary nephrons

A

5-10%

52
Q

This percentage of peritubular capillaries are in the outer medulla

A

90-95%

53
Q

This percentage of peritubular capillaries are in the inner medulla

A

5-10%

54
Q

Where does the pudendal nerve come from

A

S2, S3, S4

55
Q

What fraction of almost everything is reabsorbed at the proximal tubule?

A

2/3

56
Q

The kidney can remove about ___% of PAH as blood passes through the kidney

A

90%

57
Q

The brush border of the proximal tubule increases the surface area of its cells by ____

A

20 fold

58
Q

Membrane potential of kidney cells

A

-70 mV

59
Q

Proximal tubule tubular lumen charge

A

-3 mV

60
Q

The amount of protein filtered each day in a normal healthy person

A

1.8 grams

61
Q

How many grams of the filtered normal protein will be reabsorbed by the proximal tubule?

A

1.7 grams

62
Q

How much protein shows up in the urine in a normal healthy adult per day?

A

100 mg or 0.1 grams

63
Q

Pinocytosis only exists in this part of the kidney

A

proximal tubule

64
Q

We reabsorb ___% of the water filtered in the proximal tubule and ___% in the thin descending limb

A

65%, 20% (so 85% reabsorbed by the time we are at the end of the loop of henle)

65
Q

Tubular lumen membrane potential in thick loop of henle .WHy does it matter?

A

+8 mV

Pushes divalent cations through the paracellular route

66
Q

Lizards can get their interstitial up to ___

A

3000 mOsm

67
Q

What is the most concentrated our interstitium can be?

A

1200 mOsm

68
Q
A

AP numbers :) (4 decks)

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