Kidney in Systemic Disease Flashcards
What is the commonest cause of ESRF
Diabetic Nephropathy
What can infective endocarditis cause and how
GN
Small vessel vasculitis
Due to immune comple formation
What causes infective endocarditis
S.Aureus
Strep viridans
ENterococci
What are the symptoms of infective endocarditis in relation to the kidney
Haematruia
Abnormal u+e
Low complement
Plus standard symptoms
What systemic disease, autoimmune disease and infections can cause kidney issues
MM Amyloidosis HUS / TTP = AKI Sickle cell Pregnancy - PET / obstruct
Autoimmune SLE ANCA vasculitis HSP Systemic sclerosis Scleroderma Sarcoid Sjogren
Infection TB Malaria Hepatitis HIV
What is vasculitis
Inflammatory reaction in any blood vessel
What type of vasculitis affects large arteries
Takayasu
Giant cell
What type of vasculitis affects small arteries
Granulomatois poly
Microscopic poly
Curg-Strauss
What does granulomatous polyarteritis present with
URT- epistaxis / sinusitis / deaf LRT - cough / SOB / haemoptysis Renal - FOCAL NECROTISING GN WITH CRESCENTS Other Scleritis Pericarditis Fever Weight loss Rash
What Ab in granulomatous
C-ANCA Ab against proteinase-3
How does microscopic present
Similar presentation
More common renal
What Ab in microscopic
P-ANCA Ab against myeloperoxidase
How do you Dx vasculitis
Urinanalysis
Bloods - FBC, U+E, LFT
Ab
Renal biopsy
What is gold standard
+ve ANCA
Renal biopsy
What does urine show
Blood
Protein