Kidney Function Tests Flashcards
Increased Creatinine clearance:
High cardiac output
Pregnancy
Burns
Carbon monoxide poisoning
It is considered the best overall indicator of the level of kidney function.
Glomerular Filtration Rate/ GFR
*GFR decreases by 1.0ml/min/year after age 20-30 years.
Decreased Creatinine clearance:
Impaired kidney function
Shock, dehydration
Hemorrhage
Congestive heart failure
Better predictor of GFR than creatinine clearance in ADVANCE renal failure.
Urea clearance
Major end product of protein and amino acid catabolism- 45% of the total NPN.
Blood Urea Nitrogen / BUN
First metabolite to increase in kidney disease.
BUN
Formula from getting Urea concentration from BUN.
2.14 x BUN = urea mg%
Increased BUN
Chronic Renal Disease Stress Burns High protein diet Dehydration
Decreased BUN
Poor Nutrition
Hepatic disease
Impaired absorption (celiac disease)
Pregnancy
A measure of the completeness of 24 hour urine collection.
Creatinine
*A 24 hr urine sample with <0.8 g/day of creatinine indicates that some urine was probably discarded.
Increased Creatinine
Impaired renal function
Chronic Hepatitis
Congrstive heart failure
Decreased Creatinine
Decreased muscle mass
Advanced and severe liver disease
Pregnancy
Inadequate dietary protein
End product of muscle metabolism derived from creatine (a-methyl guanidoacetic acid)
Creatinine
Low Ratio (BUN:Crea) <10:1 (4)
Low protein diet
Acute tubular necrosis
Repeated dialysis
Hepatic disease
High ratio of BUN:Crea >20:1 WITH NORMAL CREATININE
5
Pre-renal azotemia Dehydration Catabolic states GI hemorrhage High protein diet
