Kidney Failure Flashcards
How is urine formulated?
Includes 3 complex processes:
- Glomerus filtration
- Tubular reabsorption
- Tubular Secretion
What happens in the glomerus filtration process?
- Blood flows @ 1200mls/min
- 20% enters the nephrons
- Dependant on the flow & pressure
What happens in tubular reabsorption process?
- Majority happens within the proximal tubules.
2. Reabsorption of filtrate back to the capillaries
What happens in tubular secretion process?
- Movement from capillaries to the tubular filtrate.
2. Results in 1000ml-1500mls of urine
What are the roles of the kidneys?
- Regulation of water excretion
- Regulation of electrolytes
- Regulation of acids/bases
- Auto-regulation of Blood pressure
- Vit. D synthesis
- RBC production
What does ADH do?
Anti- diuretic hormone regulates water excretion and urine concentration, varying amount of water reabsorption.
What are the 3 types of ARF?
- Pre-renal: 60-70% of cases (decreased perfusion of kidneys -damage)
- Intra-renal: Drainage to nephrons
- Post- renal: Blockage of urethra
What is ARF?
- Rapid loss of renal function
- Causes imbalance fluid and electrolytes
- Can be life threatening
- Elevated creatinine 50% above baseline
What are the phases of ARF?
- Initiation
- Oliguria
- Diuresis
- Recovery
What is the initiation phase of ARF?
Initiation:
- Injury causing event
What is Oliguria in ARF?
Oliguria is the production of small amounts of urine
1 ) F&E imbalance
2) Decreased urine output
3) Increase Ur & Cr, K,
4) Lack of Oliguria in pt taking nephrontoxic antibiotics
What is Diuresis phase in ARF?
Return of urine
How long does it take in the recovery phase of ARF?
3-12 months
What are the signs/symptoms of ARF?
- Critically ill
- Lethargic
- Nausea, vomiting, diarrhoea
- Uraemic fetor
- Dehydration of the skin
How dose ARF affect CNS?
- Drowsiness
- Headaches
- Seizures
- Muscle twitching